Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities. In an attempt to develop a new mitochondria-targeting vector, we synthesized sorbi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2021.2023696 |
| _version_ | 1828131261953081344 |
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| author | Akula S. N. Murthy Sanket Das Tejinder Singh Tae-Wan Kim Nasim Sepay Seob Jeon Jungkyun Im |
| author_facet | Akula S. N. Murthy Sanket Das Tejinder Singh Tae-Wan Kim Nasim Sepay Seob Jeon Jungkyun Im |
| author_sort | Akula S. N. Murthy |
| collection | DOAJ |
| description | As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities. In an attempt to develop a new mitochondria-targeting vector, we synthesized sorbitol-based molecular transporters with multiple guanidines, measured their partition coefficients, compared their targeting efficiency using fluorescent images and Pearson's correlation coefficients, and studied cellular uptake mechanisms. To increase the targeting ability of these molecular transporters to mitochondria, alanine-naphthalene as a lipophilic group was attached to the molecular transporter, which improved translocation across cellular membranes and led to higher accumulation in mitochondria. The molecular transporter was able to form an ionic complex with antibiotics, resulting in low cell viability. These data demonstrate that the molecular transporter with a lipophilic group could be utilized as a potential drug delivery vector for treating mitochondrial dysfunction. |
| first_indexed | 2024-04-11T16:45:03Z |
| format | Article |
| id | doaj.art-6b84a33c77e247da866ea972c53e5be4 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-11T16:45:03Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-6b84a33c77e247da866ea972c53e5be42022-12-22T04:13:35ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-0129127028310.1080/10717544.2021.20236962023696Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complexAkula S. N. Murthy0Sanket Das1Tejinder Singh2Tae-Wan Kim3Nasim Sepay4Seob Jeon5Jungkyun Im6Department of Electronic Materials and Devices Engineering, Soonchunhyang UniversityDepartment of Chemistry, Pohang University of Science and TechnologyDepartment of Electronic Materials and Devices Engineering, Soonchunhyang UniversityDepartment of Medical Life Science, Soonchunhyang UniversityDepartment of Electronic Materials and Devices Engineering, Soonchunhyang UniversityDepartment of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Cheonan HospitalDepartment of Electronic Materials and Devices Engineering, Soonchunhyang UniversityAs mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities. In an attempt to develop a new mitochondria-targeting vector, we synthesized sorbitol-based molecular transporters with multiple guanidines, measured their partition coefficients, compared their targeting efficiency using fluorescent images and Pearson's correlation coefficients, and studied cellular uptake mechanisms. To increase the targeting ability of these molecular transporters to mitochondria, alanine-naphthalene as a lipophilic group was attached to the molecular transporter, which improved translocation across cellular membranes and led to higher accumulation in mitochondria. The molecular transporter was able to form an ionic complex with antibiotics, resulting in low cell viability. These data demonstrate that the molecular transporter with a lipophilic group could be utilized as a potential drug delivery vector for treating mitochondrial dysfunction.http://dx.doi.org/10.1080/10717544.2021.2023696mitochondriatargeted-deliverydrug deliverymolecular transportermitochondrial dysfunction |
| spellingShingle | Akula S. N. Murthy Sanket Das Tejinder Singh Tae-Wan Kim Nasim Sepay Seob Jeon Jungkyun Im Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex Drug Delivery mitochondria targeted-delivery drug delivery molecular transporter mitochondrial dysfunction |
| title | Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex |
| title_full | Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex |
| title_fullStr | Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex |
| title_full_unstemmed | Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex |
| title_short | Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex |
| title_sort | mitochondria targeting molecular transporters synthesis lipophilic effect and ionic complex |
| topic | mitochondria targeted-delivery drug delivery molecular transporter mitochondrial dysfunction |
| url | http://dx.doi.org/10.1080/10717544.2021.2023696 |
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