Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers
Background: Gynecological cancers encompass all uncontrolled and aberrant cell growth in the female reproductive system, therapeutic interventions are constantly evolving, but there is still a high death rate, significant side effects and medication resistance, making the task of treatment challengi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014056 |
| _version_ | 1811187837947609088 |
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| author | Yuan Zhang Fu Peng Chenghao Yu |
| author_facet | Yuan Zhang Fu Peng Chenghao Yu |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | Background: Gynecological cancers encompass all uncontrolled and aberrant cell growth in the female reproductive system, therapeutic interventions are constantly evolving, but there is still a high death rate, significant side effects and medication resistance, making the task of treatment challenging and complex. The essential oil extracted from the rhizome of Curcuma longa is a promising natural drug, which has excellent biological activity on cancer cells and is to be developed as a new type of anti-gynecological tumor therapeutic agent. Purpose: To systematically summarize the available evidence for the efficacy of Curcuma oil and its terpenoids (β-elemene, curcumol, furanodiene, and germacrone) in gynecological cancers, primarily malignancies of the reproductive system, involving ovarian, cervical, and endometrial cancers, explain the underlying mechanisms of preventing and treating gynecological cancers, and assess the shortcomings of existing work. Results: Through several signaling channels, Curcuma oil and its terpenoids can not only stop the growth of ovarian cancer, cervical cancer, and endometrial cancer cells, limit the formation of tumors, but also raise the effectiveness of chemotherapy drugs and improve the quality of life for patients. Conclusion: It provides a preclinical basis for the efficacy of Curcuma oil as a broad-spectrum anti-tumor agent for the prevention and treatment of gynecological cancers. Even so, further efforts are still needed to improve the bioavailability of Curcuma oil and upgrade related experiments. |
| first_indexed | 2024-04-11T14:10:16Z |
| format | Article |
| id | doaj.art-6b84ef1375f144ad9310dcffbc83068b |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:10:16Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-6b84ef1375f144ad9310dcffbc83068b2022-12-22T04:19:45ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157114016Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancersYuan Zhang0Fu Peng1Chenghao Yu2State Key Laboratory of Southwestern Chinese Medicine Resources, Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaWest China School of Pharmacy, Sichuan University, Chengdu 610041, China; Corresponding authors.State Key Laboratory of Southwestern Chinese Medicine Resources, Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding authors.Background: Gynecological cancers encompass all uncontrolled and aberrant cell growth in the female reproductive system, therapeutic interventions are constantly evolving, but there is still a high death rate, significant side effects and medication resistance, making the task of treatment challenging and complex. The essential oil extracted from the rhizome of Curcuma longa is a promising natural drug, which has excellent biological activity on cancer cells and is to be developed as a new type of anti-gynecological tumor therapeutic agent. Purpose: To systematically summarize the available evidence for the efficacy of Curcuma oil and its terpenoids (β-elemene, curcumol, furanodiene, and germacrone) in gynecological cancers, primarily malignancies of the reproductive system, involving ovarian, cervical, and endometrial cancers, explain the underlying mechanisms of preventing and treating gynecological cancers, and assess the shortcomings of existing work. Results: Through several signaling channels, Curcuma oil and its terpenoids can not only stop the growth of ovarian cancer, cervical cancer, and endometrial cancer cells, limit the formation of tumors, but also raise the effectiveness of chemotherapy drugs and improve the quality of life for patients. Conclusion: It provides a preclinical basis for the efficacy of Curcuma oil as a broad-spectrum anti-tumor agent for the prevention and treatment of gynecological cancers. Even so, further efforts are still needed to improve the bioavailability of Curcuma oil and upgrade related experiments.http://www.sciencedirect.com/science/article/pii/S0753332222014056Curcuma oilGynecological cancerβ-elemeneCurcumolFuranodieneGermacrone |
| spellingShingle | Yuan Zhang Fu Peng Chenghao Yu Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers Biomedicine & Pharmacotherapy Curcuma oil Gynecological cancer β-elemene Curcumol Furanodiene Germacrone |
| title | Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers |
| title_full | Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers |
| title_fullStr | Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers |
| title_full_unstemmed | Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers |
| title_short | Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers |
| title_sort | therapeutic potential of curcuma oil and its terpenoids in gynecological cancers |
| topic | Curcuma oil Gynecological cancer β-elemene Curcumol Furanodiene Germacrone |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014056 |
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