Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study
Abstract Background Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more than one year, or the use of artificial...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-05479-8 |
| _version_ | 1797863269525880832 |
|---|---|
| author | Unnur Gudnadottir Juan Du Luisa W. Hugerth Lars Engstrand Ina Schuppe-Koistinen Eva Wiberg Itzel Emma Fransson Nele Brusselaers |
| author_facet | Unnur Gudnadottir Juan Du Luisa W. Hugerth Lars Engstrand Ina Schuppe-Koistinen Eva Wiberg Itzel Emma Fransson Nele Brusselaers |
| author_sort | Unnur Gudnadottir |
| collection | DOAJ |
| description | Abstract Background Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more than one year, or the use of artificial reproductive technologies. We aim to identify factors associated with pre-pregnancy complications and poor well-being in early pregnancy. Methods Online questionnaire data from 5330 unique pregnancies in Sweden were collected from November 2017 – February 2021. Multivariable logistic regression modelling was used to investigate potential risk factors for pre-pregnancy complications and differences in early pregnancy symptoms. Results Pre-pregnancy complications were identified in 1142 participants (21%). Risk factors included diagnosed endometriosis, thyroid medication, opioids and other strong pain medication, body mass index > 25 kg/m2 and age over 35 years. Different subgroups of pre-pregnancy complications had unique risk factors. The groups also experienced different pregnancy symptoms in early pregnancy, where women that had experienced recurrent pregnancy loss were at higher risk of depression in their current pregnancy. Conclusion We report one of the largest pregnancy cohorts with high frequency of pre-pregnancy complications compared to the Swedish population. Prescribed drug use and body weight were the top potentially modifiable risk factors in all groups. Participants that experienced pre-pregnancy complications also had higher risk of depression and pregnancy problems in early pregnancy. |
| first_indexed | 2024-04-09T22:32:51Z |
| format | Article |
| id | doaj.art-6b865cd9ec3b4a6eaa864b583da53286 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-09T22:32:51Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-6b865cd9ec3b4a6eaa864b583da532862023-03-22T12:39:00ZengBMCBMC Pregnancy and Childbirth1471-23932023-03-0123111010.1186/s12884-023-05479-8Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort studyUnnur Gudnadottir0Juan Du1Luisa W. Hugerth2Lars Engstrand3Ina Schuppe-Koistinen4Eva Wiberg Itzel5Emma Fransson6Nele Brusselaers7Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetDepartment of Clinical Science and EducationCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetAbstract Background Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more than one year, or the use of artificial reproductive technologies. We aim to identify factors associated with pre-pregnancy complications and poor well-being in early pregnancy. Methods Online questionnaire data from 5330 unique pregnancies in Sweden were collected from November 2017 – February 2021. Multivariable logistic regression modelling was used to investigate potential risk factors for pre-pregnancy complications and differences in early pregnancy symptoms. Results Pre-pregnancy complications were identified in 1142 participants (21%). Risk factors included diagnosed endometriosis, thyroid medication, opioids and other strong pain medication, body mass index > 25 kg/m2 and age over 35 years. Different subgroups of pre-pregnancy complications had unique risk factors. The groups also experienced different pregnancy symptoms in early pregnancy, where women that had experienced recurrent pregnancy loss were at higher risk of depression in their current pregnancy. Conclusion We report one of the largest pregnancy cohorts with high frequency of pre-pregnancy complications compared to the Swedish population. Prescribed drug use and body weight were the top potentially modifiable risk factors in all groups. Participants that experienced pre-pregnancy complications also had higher risk of depression and pregnancy problems in early pregnancy.https://doi.org/10.1186/s12884-023-05479-8Artificial reproductive technologiesEarly pregnancyFertilityRecurrent pregnancy lossSubfertilityLate miscarriage |
| spellingShingle | Unnur Gudnadottir Juan Du Luisa W. Hugerth Lars Engstrand Ina Schuppe-Koistinen Eva Wiberg Itzel Emma Fransson Nele Brusselaers Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study BMC Pregnancy and Childbirth Artificial reproductive technologies Early pregnancy Fertility Recurrent pregnancy loss Subfertility Late miscarriage |
| title | Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study |
| title_full | Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study |
| title_fullStr | Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study |
| title_full_unstemmed | Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study |
| title_short | Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study |
| title_sort | pre pregnancy complications associated factors and wellbeing in early pregnancy a swedish cohort study |
| topic | Artificial reproductive technologies Early pregnancy Fertility Recurrent pregnancy loss Subfertility Late miscarriage |
| url | https://doi.org/10.1186/s12884-023-05479-8 |
| work_keys_str_mv | AT unnurgudnadottir prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT juandu prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT luisawhugerth prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT larsengstrand prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT inaschuppekoistinen prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT evawibergitzel prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT emmafransson prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy AT nelebrusselaers prepregnancycomplicationsassociatedfactorsandwellbeinginearlypregnancyaswedishcohortstudy |