Transcription factor MAFB controls type I and II interferon response-mediated host immunity in Mycobacterium tuberculosis-infected macrophages

Transcription factor MAFB controls type I and II interferon response-mediated host immunity in Mycobacterium tuberculosis-infected macrophages

MAFB, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B, has been identified as a candidate gene for early tuberculosis (TB) onset in Thai and Japanese populations. Here, we investigated the genome-wide transcriptional profiles of MAFB-knockdown (KD) macrophages infected with Mycobacter...

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Bibliographic Details
Main Authors: Haruka Hikichi, Shintaro Seto, Keiko Wakabayashi, Minako Hijikata, Naoto Keicho
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
macrophage
MAFB
interferon response
RNA sequencing
gene set enrichment analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.962306/full

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