Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease
Air pollution (urban, industrial or rural) has been linked to a myriad of human ailments despite clear mechanistic associations that are often not thoroughly established. Daily variability of fine aerosols in a surveillance campaign in south Japan shows a striking coevolution between their trace ele...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2023-01-01
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| Series: | Environmental Research Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1748-9326/acd798 |
| _version_ | 1797747307412717568 |
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| author | Xavier Rodó Albert Navarro-Gallinad Tomoko Kojima Josep-Anton Morguí Silvia Borràs Alejandro Fontal |
| author_facet | Xavier Rodó Albert Navarro-Gallinad Tomoko Kojima Josep-Anton Morguí Silvia Borràs Alejandro Fontal |
| author_sort | Xavier Rodó |
| collection | DOAJ |
| description | Air pollution (urban, industrial or rural) has been linked to a myriad of human ailments despite clear mechanistic associations that are often not thoroughly established. Daily variability of fine aerosols in a surveillance campaign in south Japan shows a striking coevolution between their trace elements (metal and metalloid, MM) content and Kawasaki disease (KD) admissions, suggesting a strong dynamical link. These aerosol MM could instigate an immune response that, along with genetic susceptibility, would lead to KD development. This association may account for over 40% of the total variability in the disease, being dominated by a clear sub-weekly cycle (SWC _1 ). Thanks to both an unprecedented daily KD epidemiological record going back to 1970, light detection and ranging (LIDAR) atmospheric backscattering profiles for the interval 2010–2016 and HYSPLIT simulations with numerous sensitivity analyses, we can trace this SWC _1 variability to occur concomitantly from sub-seasonal to interannual timescales in both KD and aerosols. This SWC _1 appears to connect or disconnect Japan to air intrusions from above the planetary boundary layer (PBL), having their source in industrial and agricultural areas in NE Asia and points to a stronger case for an agricultural source for the exposure as opposed to urban pollution. The KD maxima always occur in full synchrony with the arrival of very small (<1 µ m; PM _1 ) particles showing that ultrafine aerosols appear as a necessary cofactor in the occurrence of KD and sets the field to associate other similar human diseases. Our study shows how signal-detection approaches can be useful to uncover hidden associations between the environment and human health, otherwise unnoticed and help set new early-warning systems for disease prevention. |
| first_indexed | 2024-03-12T15:48:55Z |
| format | Article |
| id | doaj.art-6b88cfa3d74344a3bf05e046f42b00dd |
| institution | Directory Open Access Journal |
| issn | 1748-9326 |
| language | English |
| last_indexed | 2024-03-12T15:48:55Z |
| publishDate | 2023-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Environmental Research Letters |
| spelling | doaj.art-6b88cfa3d74344a3bf05e046f42b00dd2023-08-09T15:17:12ZengIOP PublishingEnvironmental Research Letters1748-93262023-01-0118707401110.1088/1748-9326/acd798Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki diseaseXavier Rodó0https://orcid.org/0000-0003-4843-6180Albert Navarro-Gallinad1https://orcid.org/0000-0002-2336-753XTomoko Kojima2Josep-Anton Morguí3Silvia Borràs4https://orcid.org/0000-0002-0331-0720Alejandro Fontal5https://orcid.org/0000-0003-1138-2158ICREA , Barcelona, Catalonia, Spain; Climate and Health (CLIMA) Program, IS Global , Barcelona, Catalonia, Spain; Osaka University, Graduate School of Human Sciences , Osaka, JapanADAPT Centre for Digital Content, Trinity College Dublin , Dublin, IrelandFaculty of Advanced Science and Technology, Kumamoto University , Kumamoto, JapanClimate and Health (CLIMA) Program, IS Global , Barcelona, Catalonia, SpainClimate and Health (CLIMA) Program, IS Global , Barcelona, Catalonia, SpainClimate and Health (CLIMA) Program, IS Global , Barcelona, Catalonia, SpainAir pollution (urban, industrial or rural) has been linked to a myriad of human ailments despite clear mechanistic associations that are often not thoroughly established. Daily variability of fine aerosols in a surveillance campaign in south Japan shows a striking coevolution between their trace elements (metal and metalloid, MM) content and Kawasaki disease (KD) admissions, suggesting a strong dynamical link. These aerosol MM could instigate an immune response that, along with genetic susceptibility, would lead to KD development. This association may account for over 40% of the total variability in the disease, being dominated by a clear sub-weekly cycle (SWC _1 ). Thanks to both an unprecedented daily KD epidemiological record going back to 1970, light detection and ranging (LIDAR) atmospheric backscattering profiles for the interval 2010–2016 and HYSPLIT simulations with numerous sensitivity analyses, we can trace this SWC _1 variability to occur concomitantly from sub-seasonal to interannual timescales in both KD and aerosols. This SWC _1 appears to connect or disconnect Japan to air intrusions from above the planetary boundary layer (PBL), having their source in industrial and agricultural areas in NE Asia and points to a stronger case for an agricultural source for the exposure as opposed to urban pollution. The KD maxima always occur in full synchrony with the arrival of very small (<1 µ m; PM _1 ) particles showing that ultrafine aerosols appear as a necessary cofactor in the occurrence of KD and sets the field to associate other similar human diseases. Our study shows how signal-detection approaches can be useful to uncover hidden associations between the environment and human health, otherwise unnoticed and help set new early-warning systems for disease prevention.https://doi.org/10.1088/1748-9326/acd798aerosolshuman healthKawasaki diseaseultrafine particlesagricultural by productswind intrusions |
| spellingShingle | Xavier Rodó Albert Navarro-Gallinad Tomoko Kojima Josep-Anton Morguí Silvia Borràs Alejandro Fontal Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease Environmental Research Letters aerosols human health Kawasaki disease ultrafine particles agricultural by products wind intrusions |
| title | Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease |
| title_full | Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease |
| title_fullStr | Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease |
| title_full_unstemmed | Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease |
| title_short | Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease |
| title_sort | sub weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to kawasaki disease |
| topic | aerosols human health Kawasaki disease ultrafine particles agricultural by products wind intrusions |
| url | https://doi.org/10.1088/1748-9326/acd798 |
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