Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context
Summary: Background: The Philippines reports a high prevalence of soil-transmitted helminth (STH) infections despite the implementation of nationwide mass drug administration since 2006. The spatial variation of STH infections in the Philippines was last described using the 2005–2007 national STH a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
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| Series: | The Lancet Regional Health. Western Pacific |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666606523002924 |
| _version_ | 1827631709638623232 |
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| author | Tsheten Tsheten Kefyalew Addis Alene Angela Cadavid Restrepo Matthew Kelly Colleen Lau Archie C.A. Clements Darren J. Gray Chona Daga Vanessa Joy Mapalo Fe Esperanza Espino Kinley Wangdi |
| author_facet | Tsheten Tsheten Kefyalew Addis Alene Angela Cadavid Restrepo Matthew Kelly Colleen Lau Archie C.A. Clements Darren J. Gray Chona Daga Vanessa Joy Mapalo Fe Esperanza Espino Kinley Wangdi |
| author_sort | Tsheten Tsheten |
| collection | DOAJ |
| description | Summary: Background: The Philippines reports a high prevalence of soil-transmitted helminth (STH) infections despite the implementation of nationwide mass drug administration since 2006. The spatial variation of STH infections in the Philippines was last described using the 2005–2007 national STH and schistosomiasis survey. This study aimed to identify sociodemographic and environmental factors that drive STH transmission and predict high-risk areas in the Philippines. Methods: Epidemiological data on STH for students aged 5–16 years were obtained from the 2015 Philippines National Prevalence survey, while environmental data were extracted from satellite images and publicly available sources. Model-based geostatistics, implemented in a Bayesian framework, was used to identify sociodemographic and environmental correlates and predict high-risk areas for STH across the Philippines. The best-fitting model with the lowest deviance information criterion (DIC) was used to interpret the findings of the model and predict STH infection risk for the entire country. Risk maps were developed for each STH infection using the posterior means derived from the model. Findings: The prevalence of Ascaris lumbricoides (20.0%) and Trichuris trichiura (29.3%) was higher in the Visayas Island than in the Luzon and Mindanao Islands. Hookworm prevalence was highest in Mindanao Island (1.3%). Risk of A. lumbricoides was positively associated with males (odds ratio [OR]: 1.197; 97.5% Credible Interval [CrI]: 1.114, 1.286) and temperature (OR: 1.148; 97.5% CrI: 1.033, 1.291), while normalized difference vegetation index (OR: 0.354; 97.5% CrI: 0.138, 0.930) and soil pH (OR: 0.606; 97.5% CrI: 0.338, 0.949) were negatively associated with the transmission. T. trichiura risk was positively associated with males (OR: 1.261; 97.5% CrI: 1.173, 1.341), temperature (OR: 1.153; 97.5% CrI: 1.001, 1.301), and rainfall (OR: 1.004; 97.5% CrI: 1.011, 1.069). Hookworm risk was positively associated with males (OR: 2.142; 97.5% CrI: 1.537, 2.998), while children aged ≤12 years (OR: 0.435; 97.5% CrI: 0.252, 0.753) had a negative association with risk compared to those over 12 years. Focal areas of high risk were identified for A. lumbricoides and T. trichiura in the Visayas Island, and hookworm in the Mindanao Island. Interpretation: The spatial distribution of all three STH infections has considerably decreased since a previous national risk-mapping exercise. The high-risk areas identified in the study can be used to strategically target deworming and health education activities to further reduce the burden of STH and support progress toward elimination. Funding: The Australian Centre for the Control and Elimination of Neglected Tropical Diseases and the Australian National Health and Medical Research Council. |
| first_indexed | 2024-03-09T14:24:54Z |
| format | Article |
| id | doaj.art-6b8972cc087f418f835e9eef0a674305 |
| institution | Directory Open Access Journal |
| issn | 2666-6065 |
| language | English |
| last_indexed | 2024-03-09T14:24:54Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj.art-6b8972cc087f418f835e9eef0a6743052023-11-28T07:27:06ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652024-02-0143100974Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in contextTsheten Tsheten0Kefyalew Addis Alene1Angela Cadavid Restrepo2Matthew Kelly3Colleen Lau4Archie C.A. Clements5Darren J. Gray6Chona Daga7Vanessa Joy Mapalo8Fe Esperanza Espino9Kinley Wangdi10National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australia; Corresponding author. 62 Mills Road, Acton, ACT 2601, Australia.Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Australia; Geospatial and Tuberculosis Research Team, Telethon Kids Institute, AustraliaSchool of Public Health, The University of Queensland, AustraliaNational Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, AustraliaSchool of Public Health, The University of Queensland, AustraliaResearch and Innovation, University of Plymouth, United KingdomQIMR Berghofer Medical Research Institute, Herston Rd Herston, QLD, AustraliaDepartment of Health, Research Institute for Tropical Medicine, PhilippinesDepartment of Health, Research Institute for Tropical Medicine, PhilippinesDepartment of Health, Research Institute for Tropical Medicine, PhilippinesNational Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australia; QIMR Berghofer Medical Research Institute, Herston Rd Herston, QLD, AustraliaSummary: Background: The Philippines reports a high prevalence of soil-transmitted helminth (STH) infections despite the implementation of nationwide mass drug administration since 2006. The spatial variation of STH infections in the Philippines was last described using the 2005–2007 national STH and schistosomiasis survey. This study aimed to identify sociodemographic and environmental factors that drive STH transmission and predict high-risk areas in the Philippines. Methods: Epidemiological data on STH for students aged 5–16 years were obtained from the 2015 Philippines National Prevalence survey, while environmental data were extracted from satellite images and publicly available sources. Model-based geostatistics, implemented in a Bayesian framework, was used to identify sociodemographic and environmental correlates and predict high-risk areas for STH across the Philippines. The best-fitting model with the lowest deviance information criterion (DIC) was used to interpret the findings of the model and predict STH infection risk for the entire country. Risk maps were developed for each STH infection using the posterior means derived from the model. Findings: The prevalence of Ascaris lumbricoides (20.0%) and Trichuris trichiura (29.3%) was higher in the Visayas Island than in the Luzon and Mindanao Islands. Hookworm prevalence was highest in Mindanao Island (1.3%). Risk of A. lumbricoides was positively associated with males (odds ratio [OR]: 1.197; 97.5% Credible Interval [CrI]: 1.114, 1.286) and temperature (OR: 1.148; 97.5% CrI: 1.033, 1.291), while normalized difference vegetation index (OR: 0.354; 97.5% CrI: 0.138, 0.930) and soil pH (OR: 0.606; 97.5% CrI: 0.338, 0.949) were negatively associated with the transmission. T. trichiura risk was positively associated with males (OR: 1.261; 97.5% CrI: 1.173, 1.341), temperature (OR: 1.153; 97.5% CrI: 1.001, 1.301), and rainfall (OR: 1.004; 97.5% CrI: 1.011, 1.069). Hookworm risk was positively associated with males (OR: 2.142; 97.5% CrI: 1.537, 2.998), while children aged ≤12 years (OR: 0.435; 97.5% CrI: 0.252, 0.753) had a negative association with risk compared to those over 12 years. Focal areas of high risk were identified for A. lumbricoides and T. trichiura in the Visayas Island, and hookworm in the Mindanao Island. Interpretation: The spatial distribution of all three STH infections has considerably decreased since a previous national risk-mapping exercise. The high-risk areas identified in the study can be used to strategically target deworming and health education activities to further reduce the burden of STH and support progress toward elimination. Funding: The Australian Centre for the Control and Elimination of Neglected Tropical Diseases and the Australian National Health and Medical Research Council.http://www.sciencedirect.com/science/article/pii/S2666606523002924Soil-transmitted helminthsAscarisTrichurisHookwormPhilippinesBayesian modelling |
| spellingShingle | Tsheten Tsheten Kefyalew Addis Alene Angela Cadavid Restrepo Matthew Kelly Colleen Lau Archie C.A. Clements Darren J. Gray Chona Daga Vanessa Joy Mapalo Fe Esperanza Espino Kinley Wangdi Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context The Lancet Regional Health. Western Pacific Soil-transmitted helminths Ascaris Trichuris Hookworm Philippines Bayesian modelling |
| title | Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context |
| title_full | Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context |
| title_fullStr | Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context |
| title_full_unstemmed | Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context |
| title_short | Risk mapping and socio-ecological drivers of soil-transmitted helminth infections in the Philippines: a spatial modelling studyResearch in context |
| title_sort | risk mapping and socio ecological drivers of soil transmitted helminth infections in the philippines a spatial modelling studyresearch in context |
| topic | Soil-transmitted helminths Ascaris Trichuris Hookworm Philippines Bayesian modelling |
| url | http://www.sciencedirect.com/science/article/pii/S2666606523002924 |
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