<i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial
Emerging science shows that probiotic intake may impact stress and mental health. We investigated the effect of a 6-week intervention with <i>Bifidobacterium longum (BL) NCC3001</i> (1 × 10<sup>10</sup> CFU/daily) on stress-related psychological and physiological parameters i...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/14/3122 |
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| author | Marcus Boehme Noëla Rémond-Derbez Clara Lerond Luca Lavalle Sonia Keddani Myriam Steinmann Andreas Rytz Boushra Dalile Kristin Verbeke Lukas Van Oudenhove Pascal Steiner Bernard Berger Maria Vicario Gabriela Bergonzelli Sara Colombo Mottaz Julie Hudry |
| author_facet | Marcus Boehme Noëla Rémond-Derbez Clara Lerond Luca Lavalle Sonia Keddani Myriam Steinmann Andreas Rytz Boushra Dalile Kristin Verbeke Lukas Van Oudenhove Pascal Steiner Bernard Berger Maria Vicario Gabriela Bergonzelli Sara Colombo Mottaz Julie Hudry |
| author_sort | Marcus Boehme |
| collection | DOAJ |
| description | Emerging science shows that probiotic intake may impact stress and mental health. We investigated the effect of a 6-week intervention with <i>Bifidobacterium longum (BL) NCC3001</i> (1 × 10<sup>10</sup> CFU/daily) on stress-related psychological and physiological parameters in 45 healthy adults with mild-to-moderate stress using a randomized, placebo-controlled, two-arm, parallel, double-blind design. The main results showed that supplementation with the probiotic significantly reduced the perceived stress and improved the subjective sleep quality score compared to placebo. Comparing the two groups, momentary subjective assessments concomitant to the Maastricht Acute Stress Test revealed a lower amount of pain experience in the probiotic group and a higher amount of relief at the end of the procedure in the placebo group, reflected by higher scores in the positive affect state. The awakening of the salivary cortisol response was not affected by the intervention, yet the reduction observed in the salivary cortisol stress response post-intervention was higher in the placebo group than the probiotic group. Multivariate analysis further indicated that a reduction in perceived stress correlated with a reduction in anxiety, in depression, and in the cortisol awakening response after the 6-week intervention. This exploratory trial provides promising insights into <i>BL NCC3001</i> to reduce perceived stress in a healthy population and supports the potential of nutritional solutions including probiotics to improve mental health. |
| first_indexed | 2024-03-11T00:45:58Z |
| format | Article |
| id | doaj.art-6b8be2751d504750a941d8c96b7f37ad |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:45:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6b8be2751d504750a941d8c96b7f37ad2023-11-18T20:47:30ZengMDPI AGNutrients2072-66432023-07-011514312210.3390/nu15143122<i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical TrialMarcus Boehme0Noëla Rémond-Derbez1Clara Lerond2Luca Lavalle3Sonia Keddani4Myriam Steinmann5Andreas Rytz6Boushra Dalile7Kristin Verbeke8Lukas Van Oudenhove9Pascal Steiner10Bernard Berger11Maria Vicario12Gabriela Bergonzelli13Sara Colombo Mottaz14Julie Hudry15Nestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandClinical Research Unit, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandClinical Research Unit, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandTranslational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, 3000 Leuven, BelgiumNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandClinical Research Unit, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé S.A., 1000 Lausanne 26, SwitzerlandEmerging science shows that probiotic intake may impact stress and mental health. We investigated the effect of a 6-week intervention with <i>Bifidobacterium longum (BL) NCC3001</i> (1 × 10<sup>10</sup> CFU/daily) on stress-related psychological and physiological parameters in 45 healthy adults with mild-to-moderate stress using a randomized, placebo-controlled, two-arm, parallel, double-blind design. The main results showed that supplementation with the probiotic significantly reduced the perceived stress and improved the subjective sleep quality score compared to placebo. Comparing the two groups, momentary subjective assessments concomitant to the Maastricht Acute Stress Test revealed a lower amount of pain experience in the probiotic group and a higher amount of relief at the end of the procedure in the placebo group, reflected by higher scores in the positive affect state. The awakening of the salivary cortisol response was not affected by the intervention, yet the reduction observed in the salivary cortisol stress response post-intervention was higher in the placebo group than the probiotic group. Multivariate analysis further indicated that a reduction in perceived stress correlated with a reduction in anxiety, in depression, and in the cortisol awakening response after the 6-week intervention. This exploratory trial provides promising insights into <i>BL NCC3001</i> to reduce perceived stress in a healthy population and supports the potential of nutritional solutions including probiotics to improve mental health.https://www.mdpi.com/2072-6643/15/14/3122probioticpsychological stresssleepcortisolgut–brain axis |
| spellingShingle | Marcus Boehme Noëla Rémond-Derbez Clara Lerond Luca Lavalle Sonia Keddani Myriam Steinmann Andreas Rytz Boushra Dalile Kristin Verbeke Lukas Van Oudenhove Pascal Steiner Bernard Berger Maria Vicario Gabriela Bergonzelli Sara Colombo Mottaz Julie Hudry <i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial Nutrients probiotic psychological stress sleep cortisol gut–brain axis |
| title | <i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial |
| title_full | <i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial |
| title_fullStr | <i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial |
| title_full_unstemmed | <i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial |
| title_short | <i>Bifidobacterium longum</i> subsp. <i>longum</i> Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial |
| title_sort | i bifidobacterium longum i subsp i longum i reduces perceived psychological stress in healthy adults an exploratory clinical trial |
| topic | probiotic psychological stress sleep cortisol gut–brain axis |
| url | https://www.mdpi.com/2072-6643/15/14/3122 |
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