Regulatory Functions of L-Carnitine, Acetyl, and Propionyl L-Carnitine in a PCOS Mouse Model: Focus on Antioxidant/Antiglycative Molecular Pathways in the Ovarian Microenvironment

Regulatory Functions of L-Carnitine, Acetyl, and Propionyl L-Carnitine in a PCOS Mouse Model: Focus on Antioxidant/Antiglycative Molecular Pathways in the Ovarian Microenvironment

Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with female infertility. Based on energy and antioxidant regulatory functions of carnitines, we investigated whether acyl-L-carnitines improve PCOS phenotype in a mouse model induced by dehydroepiandrosterone (DHEA). CD1 mic...

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Bibliographic Details
Main Authors: Giovanna Di Emidio, Francesco Rea, Martina Placidi, Giulia Rossi, Domenica Cocciolone, Ashraf Virmani, Guido Macchiarelli, Maria Grazia Palmerini, Anna Maria D’Alessandro, Paolo Giovanni Artini, Carla Tatone
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
PCOS
L-carnitine (LC)
acetyl-L-carnitine (ALC)
propionyl-L-carnitine (PLC)
mitochondria
advanced glycation end-products
Online Access:https://www.mdpi.com/2076-3921/9/9/867

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