Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery
ABSTRACT Introduction: The objectives of this study are to experimentally evaluate the haemostatic effects of two organic substances, a membrane of chitosan and a collagen sponge coated with thrombin and human fibrinogen (TachoSil®), in sealing 7-0 needle stitches holes on the femoral arteries of r...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
2022-04-01
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022005003213&lng=en&tlng=en |
| _version_ | 1818252770643279872 |
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| author | Renan Nalin dos Santos Guinea Brasil Camargo Cardoso Marcelo Rodrigues Cunha Evaldo Marchi Marcus V. H Carvalho |
| author_facet | Renan Nalin dos Santos Guinea Brasil Camargo Cardoso Marcelo Rodrigues Cunha Evaldo Marchi Marcus V. H Carvalho |
| author_sort | Renan Nalin dos Santos |
| collection | DOAJ |
| description | ABSTRACT Introduction: The objectives of this study are to experimentally evaluate the haemostatic effects of two organic substances, a membrane of chitosan and a collagen sponge coated with thrombin and human fibrinogen (TachoSil®), in sealing 7-0 needle stitches holes on the femoral arteries of rats as well as to evaluate local histological reactions. Methods: Twenty-four rats were included, and four holes were made in each common femoral artery. In the control group, haemostasis was achieved only by compression with gauze sponge; and in the two other groups, haemostasis was achieved with application of one of these two substances. Results: Membrane of chitosan and TachoSil® showed a power to reduce the time to achieve haemostasis compared with the control group (P=0.001), and the haemostatic effects of these two substances were comparable. There was lower blood loss in the groups where these two substances were used when compared with the control group, but no difference was found comparing the two substances. Conclusion: The use of these sealants did not promote more adhesion or local histological reactions when compared to the control group. Since chitosan is easy to find in nature, has a positive effect to promote haemostasis, and did not bring considerable local reactions, it might be used as a sealant in cardiovascular surgery. |
| first_indexed | 2024-12-12T16:29:28Z |
| format | Article |
| id | doaj.art-6b8ca6b09ed141cabba8acb87422a687 |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-12-12T16:29:28Z |
| publishDate | 2022-04-01 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-6b8ca6b09ed141cabba8acb87422a6872022-12-22T00:18:49ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412022-04-0110.21470/1678-9741-2021-0432Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular SurgeryRenan Nalin dos SantosGuinea Brasil Camargo CardosoMarcelo Rodrigues CunhaEvaldo MarchiMarcus V. H Carvalhohttps://orcid.org/0000-0003-3911-370XABSTRACT Introduction: The objectives of this study are to experimentally evaluate the haemostatic effects of two organic substances, a membrane of chitosan and a collagen sponge coated with thrombin and human fibrinogen (TachoSil®), in sealing 7-0 needle stitches holes on the femoral arteries of rats as well as to evaluate local histological reactions. Methods: Twenty-four rats were included, and four holes were made in each common femoral artery. In the control group, haemostasis was achieved only by compression with gauze sponge; and in the two other groups, haemostasis was achieved with application of one of these two substances. Results: Membrane of chitosan and TachoSil® showed a power to reduce the time to achieve haemostasis compared with the control group (P=0.001), and the haemostatic effects of these two substances were comparable. There was lower blood loss in the groups where these two substances were used when compared with the control group, but no difference was found comparing the two substances. Conclusion: The use of these sealants did not promote more adhesion or local histological reactions when compared to the control group. Since chitosan is easy to find in nature, has a positive effect to promote haemostasis, and did not bring considerable local reactions, it might be used as a sealant in cardiovascular surgery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022005003213&lng=en&tlng=enFemoral ArteryFibrin Tissue AdhesiveCaHemostaticsFibrinogenCatheterizationCardiovascular Surgical Procedures |
| spellingShingle | Renan Nalin dos Santos Guinea Brasil Camargo Cardoso Marcelo Rodrigues Cunha Evaldo Marchi Marcus V. H Carvalho Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery Brazilian Journal of Cardiovascular Surgery Femoral Artery Fibrin Tissue Adhesive Ca Hemostatics Fibrinogen Catheterization Cardiovascular Surgical Procedures |
| title | Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery |
| title_full | Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery |
| title_fullStr | Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery |
| title_full_unstemmed | Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery |
| title_short | Experimental Evaluation of Chitosan Membrane and Collagen Sponge (TachoSil®) as Sealants in Cardiovascular Surgery |
| title_sort | experimental evaluation of chitosan membrane and collagen sponge tachosil r as sealants in cardiovascular surgery |
| topic | Femoral Artery Fibrin Tissue Adhesive Ca Hemostatics Fibrinogen Catheterization Cardiovascular Surgical Procedures |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022005003213&lng=en&tlng=en |
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