Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals
Abstract Upregulation of endothelin‐1 (ET‐1) is the hallmark of various cardiovascular diseases (CVD). The purpose of the present study was to assess the ET‐1 response to an acute bout of whole‐body vibration (WBV) in humans and to determine the role of adiposity. Twenty‐two participants volunteered...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15335 |
| _version_ | 1827580941424394240 |
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| author | Adeola A. Sanni‐Ajibaye Anson M. Blanks Cassandra C. Derella Abigayle B. Simon Paula Rodriguez‐Miguelez Jacob Looney Jinhee Jeong Jeffrey Thomas David W. Stepp Neal L. Weintraub Xiaoling Wang Ryan A. Harris |
| author_facet | Adeola A. Sanni‐Ajibaye Anson M. Blanks Cassandra C. Derella Abigayle B. Simon Paula Rodriguez‐Miguelez Jacob Looney Jinhee Jeong Jeffrey Thomas David W. Stepp Neal L. Weintraub Xiaoling Wang Ryan A. Harris |
| author_sort | Adeola A. Sanni‐Ajibaye |
| collection | DOAJ |
| description | Abstract Upregulation of endothelin‐1 (ET‐1) is the hallmark of various cardiovascular diseases (CVD). The purpose of the present study was to assess the ET‐1 response to an acute bout of whole‐body vibration (WBV) in humans and to determine the role of adiposity. Twenty‐two participants volunteered for the study; they were grouped into overweight/obese [(OW/OB): n = 11, Age: 33 ± 4 years, Body mass index (BMI): 35 ± 10 kg/m2] or normal weight [(NW): n = 11, Age: 28 ± 7 years, BMI: 21 ± 2 kg/m2]. Participants engaged in 10 cycles of WBV exercise (1 cycle = 1 min WBV followed by 30 s of rest). Blood samples were analyzed for ET‐1 pre‐WBV (PRE), immediately post (POST), 1 h (1H), 3 h (3H), and 24 h (24H) post‐WBV. There was a significant time main effect of WBV on circulating ET‐1 (F = 12.5, p < 0.001); however, the ET‐1 response was similar (F = 0.180, p = 0.677) between groups. Specifically, compared to PRE, a significant increase in ET‐1 was observed at 1H (p = 0.017) and 3H (p = 0.025). In addition, concentrations of ET‐1 were significantly lower at 24H compared to PRE (p = 0.019), 1H (p < 0.001), and 3H (p < 0.001). Maximal oxygen uptake during WBV was similar between the two groups. Acute WBV resulted in an initial rise in ET‐1, followed by a significantly lower ET‐1 at 24H in both groups. Findings support the utility of routine WBV exercise to elicit a decrease in ET‐1 and improve CVD risk, similar to what has been reported with traditional modes of exercise. |
| first_indexed | 2024-03-08T22:27:24Z |
| format | Article |
| id | doaj.art-6b8d81ce13d746569de7b459d88885a1 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T22:27:24Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-6b8d81ce13d746569de7b459d88885a12023-12-18T09:26:14ZengWileyPhysiological Reports2051-817X2022-05-011010n/an/a10.14814/phy2.15335Endothelin‐1 response to whole‐body vibration in obese and normal weight individualsAdeola A. Sanni‐Ajibaye0Anson M. Blanks1Cassandra C. Derella2Abigayle B. Simon3Paula Rodriguez‐Miguelez4Jacob Looney5Jinhee Jeong6Jeffrey Thomas7David W. Stepp8Neal L. Weintraub9Xiaoling Wang10Ryan A. Harris11Department of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Kinesiology and Health Sciences Virginia Commonwealth University Richmond Virginia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USAVascular Biology Center Augusta University Augusta Georgia USAVascular Biology Center Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USADepartment of Medicine Georgia Prevention Institute Augusta University Augusta Georgia USAAbstract Upregulation of endothelin‐1 (ET‐1) is the hallmark of various cardiovascular diseases (CVD). The purpose of the present study was to assess the ET‐1 response to an acute bout of whole‐body vibration (WBV) in humans and to determine the role of adiposity. Twenty‐two participants volunteered for the study; they were grouped into overweight/obese [(OW/OB): n = 11, Age: 33 ± 4 years, Body mass index (BMI): 35 ± 10 kg/m2] or normal weight [(NW): n = 11, Age: 28 ± 7 years, BMI: 21 ± 2 kg/m2]. Participants engaged in 10 cycles of WBV exercise (1 cycle = 1 min WBV followed by 30 s of rest). Blood samples were analyzed for ET‐1 pre‐WBV (PRE), immediately post (POST), 1 h (1H), 3 h (3H), and 24 h (24H) post‐WBV. There was a significant time main effect of WBV on circulating ET‐1 (F = 12.5, p < 0.001); however, the ET‐1 response was similar (F = 0.180, p = 0.677) between groups. Specifically, compared to PRE, a significant increase in ET‐1 was observed at 1H (p = 0.017) and 3H (p = 0.025). In addition, concentrations of ET‐1 were significantly lower at 24H compared to PRE (p = 0.019), 1H (p < 0.001), and 3H (p < 0.001). Maximal oxygen uptake during WBV was similar between the two groups. Acute WBV resulted in an initial rise in ET‐1, followed by a significantly lower ET‐1 at 24H in both groups. Findings support the utility of routine WBV exercise to elicit a decrease in ET‐1 and improve CVD risk, similar to what has been reported with traditional modes of exercise.https://doi.org/10.14814/phy2.15335adiposityendothelin‐1exercisewhole‐body vibration |
| spellingShingle | Adeola A. Sanni‐Ajibaye Anson M. Blanks Cassandra C. Derella Abigayle B. Simon Paula Rodriguez‐Miguelez Jacob Looney Jinhee Jeong Jeffrey Thomas David W. Stepp Neal L. Weintraub Xiaoling Wang Ryan A. Harris Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals Physiological Reports adiposity endothelin‐1 exercise whole‐body vibration |
| title | Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals |
| title_full | Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals |
| title_fullStr | Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals |
| title_full_unstemmed | Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals |
| title_short | Endothelin‐1 response to whole‐body vibration in obese and normal weight individuals |
| title_sort | endothelin 1 response to whole body vibration in obese and normal weight individuals |
| topic | adiposity endothelin‐1 exercise whole‐body vibration |
| url | https://doi.org/10.14814/phy2.15335 |
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