Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects
We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate (AHI). Results show that after 24 h o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2021.1967918 |
| _version_ | 1797684138807918592 |
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| author | Oscar Salva Roxana Alasino Celia Giller Julieta Borello Alexis Doresky Galia Karayan Dante Beltramo |
| author_facet | Oscar Salva Roxana Alasino Celia Giller Julieta Borello Alexis Doresky Galia Karayan Dante Beltramo |
| author_sort | Oscar Salva |
| collection | DOAJ |
| description | We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate (AHI). Results show that after 24 h of nebulization with AHI, circulating platelets shows an increase about 40% at 24 h and reach 65% at 96 h. In patients with platelets content below 200,000 by microliter the increase was 49% and 79% at 24 and 96 h respectively. In patients with platelets above 200,000 by microliter the increase was 24% and 31% at 24 and 96 h, respectively. The increase of platelets via AHI was similar in both, men and women. To evaluate whether this action of AHI was related to platelets from COVID-19 positive patients or also for healthy people, two controls were included: one of them with 10 healthy volunteers and another one with COVID-19 positive patients hospitalized and treated only with Dexa-Enoxa. Results show that, in healthy volunteers, the number of circulating platelets remains unchanged even after 7 days of treatment with AHI. In COVID-19 positive patients treated only with Dexa-Enoxa for 4 days, platelets increased only 16%. |
| first_indexed | 2024-03-12T00:25:10Z |
| format | Article |
| id | doaj.art-6b8daea79478473e9db1ff571754e865 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:10Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-6b8daea79478473e9db1ff571754e8652023-09-15T10:38:10ZengTaylor & Francis GroupPlatelets0953-71041369-16352022-04-0133347147810.1080/09537104.2021.19679181967918Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjectsOscar Salva0Roxana Alasino1Celia Giller2Julieta Borello3Alexis Doresky4Galia Karayan5Dante Beltramo6Clínica Independencia, Ciudad de Munro, Provincia de Buenos AiresCentro De Excelencias En Productos Y Procesos (CEPROCOR), Ministerio de Ciencia y Tecnología de la Provincia de CórdobaClínica Independencia, Ciudad de Munro, Provincia de Buenos AiresCentro De Excelencias En Productos Y Procesos (CEPROCOR), Ministerio de Ciencia y Tecnología de la Provincia de CórdobaFundación Respirar, Ciudad Autónoma de Buenos AiresFundación Respirar, Ciudad Autónoma de Buenos AiresCentro De Excelencias En Productos Y Procesos (CEPROCOR), Ministerio de Ciencia y Tecnología de la Provincia de CórdobaWe analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate (AHI). Results show that after 24 h of nebulization with AHI, circulating platelets shows an increase about 40% at 24 h and reach 65% at 96 h. In patients with platelets content below 200,000 by microliter the increase was 49% and 79% at 24 and 96 h respectively. In patients with platelets above 200,000 by microliter the increase was 24% and 31% at 24 and 96 h, respectively. The increase of platelets via AHI was similar in both, men and women. To evaluate whether this action of AHI was related to platelets from COVID-19 positive patients or also for healthy people, two controls were included: one of them with 10 healthy volunteers and another one with COVID-19 positive patients hospitalized and treated only with Dexa-Enoxa. Results show that, in healthy volunteers, the number of circulating platelets remains unchanged even after 7 days of treatment with AHI. In COVID-19 positive patients treated only with Dexa-Enoxa for 4 days, platelets increased only 16%.http://dx.doi.org/10.1080/09537104.2021.1967918covid-19hypertonic alkaline ibuprofenatenebulizationplatelets recruitment |
| spellingShingle | Oscar Salva Roxana Alasino Celia Giller Julieta Borello Alexis Doresky Galia Karayan Dante Beltramo Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects Platelets covid-19 hypertonic alkaline ibuprofenate nebulization platelets recruitment |
| title | Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects |
| title_full | Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects |
| title_fullStr | Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects |
| title_full_unstemmed | Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects |
| title_short | Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects |
| title_sort | nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in covid 19 patients but not in healthy subjects |
| topic | covid-19 hypertonic alkaline ibuprofenate nebulization platelets recruitment |
| url | http://dx.doi.org/10.1080/09537104.2021.1967918 |
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