Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis
Summary: Recent studies have proposed that adequate intake of Vitamin K (VK) is associated with a low risk of fracture and high bone mineral density (BMD) to improve skeletal health in adults. This systematic review was designed to summarize the most relevant and updated evidence discussing the rela...
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MDPI AG
2022-05-01
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1048 |
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| author | Salma Syed Sufian Ahmad Shahid Karim Ibrahim M. Ibrahim Huda M. Alkreathy Mohammed Alsieni Mohammad Ahmed Khan |
| author_facet | Salma Syed Sufian Ahmad Shahid Karim Ibrahim M. Ibrahim Huda M. Alkreathy Mohammed Alsieni Mohammad Ahmed Khan |
| author_sort | Salma |
| collection | DOAJ |
| description | Summary: Recent studies have proposed that adequate intake of Vitamin K (VK) is associated with a low risk of fracture and high bone mineral density (BMD) to improve skeletal health in adults. This systematic review was designed to summarize the most relevant and updated evidence discussing the relationship between VK and bone. It explores the effect of VK deficiency and its supplementation on various bone parameters. Methods: The distinct databases such as PubMed, the Cochrane Library, Google Scholar, National Clinical Trials, Current Controlled Trials, and Clinical Trials were searched up to Jan 2020 to identify eligible trials. All relevant randomized controlled trial studies with any oral dosage form of VK supplement administered for at least six months and assessing BMD or fracture in adults were extracted. Finally, two independent reviewers identified 20 relevant citations for the systematic review and extracted data in tabular form. Results: The meta-analysis was performed with all studies, including postmenopausal and osteoporotic females, for both total clinical and vertebral fracture outcomes. The quantitative analysis showed that the odds ratios (OR) of any fracture were lower for VK as compared to control [OR 0.42 (95% CI 0.27 to 0.66)] for vertebral fractures and OR of 0.44 (95% CI 0.23 to 0.88) for clinical fracture. For the BMD, a meta-analysis of the pooled effect of interventional studies suggested a non-significant association between the use of VK and improvement in femoral BMD (CI 95%, <i>p</i> = 0.08 [−0.03–0.20]). <b>Conclusion:</b> VK decreases general fracture risk, and it can be an option to counter bone loss disorders. However, insufficient evidence is available regarding the significant impact of VK on femoral neck BMD. Therefore, further studies are required to establish the therapeutic value of VK as a treatment for osteoporosis. |
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| series | Biomedicines |
| spelling | doaj.art-6b8dd1112638457298ac48c02c5175932023-11-23T10:10:17ZengMDPI AGBiomedicines2227-90592022-05-01105104810.3390/biomedicines10051048Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-AnalysisSalma0Syed Sufian Ahmad1Shahid Karim2Ibrahim M. Ibrahim3Huda M. Alkreathy4Mohammed Alsieni5Mohammad Ahmed Khan6Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi 110025, IndiaDepartment of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi 110025, IndiaDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi 110025, IndiaSummary: Recent studies have proposed that adequate intake of Vitamin K (VK) is associated with a low risk of fracture and high bone mineral density (BMD) to improve skeletal health in adults. This systematic review was designed to summarize the most relevant and updated evidence discussing the relationship between VK and bone. It explores the effect of VK deficiency and its supplementation on various bone parameters. Methods: The distinct databases such as PubMed, the Cochrane Library, Google Scholar, National Clinical Trials, Current Controlled Trials, and Clinical Trials were searched up to Jan 2020 to identify eligible trials. All relevant randomized controlled trial studies with any oral dosage form of VK supplement administered for at least six months and assessing BMD or fracture in adults were extracted. Finally, two independent reviewers identified 20 relevant citations for the systematic review and extracted data in tabular form. Results: The meta-analysis was performed with all studies, including postmenopausal and osteoporotic females, for both total clinical and vertebral fracture outcomes. The quantitative analysis showed that the odds ratios (OR) of any fracture were lower for VK as compared to control [OR 0.42 (95% CI 0.27 to 0.66)] for vertebral fractures and OR of 0.44 (95% CI 0.23 to 0.88) for clinical fracture. For the BMD, a meta-analysis of the pooled effect of interventional studies suggested a non-significant association between the use of VK and improvement in femoral BMD (CI 95%, <i>p</i> = 0.08 [−0.03–0.20]). <b>Conclusion:</b> VK decreases general fracture risk, and it can be an option to counter bone loss disorders. However, insufficient evidence is available regarding the significant impact of VK on femoral neck BMD. Therefore, further studies are required to establish the therapeutic value of VK as a treatment for osteoporosis.https://www.mdpi.com/2227-9059/10/5/1048bone mineral densityfracturesosteoporosissystematic reviewVitamin K |
| spellingShingle | Salma Syed Sufian Ahmad Shahid Karim Ibrahim M. Ibrahim Huda M. Alkreathy Mohammed Alsieni Mohammad Ahmed Khan Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis Biomedicines bone mineral density fractures osteoporosis systematic review Vitamin K |
| title | Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis |
| title_full | Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis |
| title_fullStr | Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis |
| title_short | Effect of Vitamin K on Bone Mineral Density and Fracture Risk in Adults: Systematic Review and Meta-Analysis |
| title_sort | effect of vitamin k on bone mineral density and fracture risk in adults systematic review and meta analysis |
| topic | bone mineral density fractures osteoporosis systematic review Vitamin K |
| url | https://www.mdpi.com/2227-9059/10/5/1048 |
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