A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

Huntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with an expanded polyQ stretch. While Htt is ubiquitously expressed, HD is characterized by selective neurodege...

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Bibliographic Details
Main Authors: Yuwei Yao, Xiaotian Cui, Ismael Al-Ramahi, Xiaoli Sun, Bo Li, Jiapeng Hou, Marian Difiglia, James Palacino, Zhi-Ying Wu, Lixiang Ma, Juan Botas, Boxun Lu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
polyQ
neurodegeneration
GPCR
huntington's disease
cyclic AMP
intron
Online Access:https://elifesciences.org/articles/05449

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