MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis
Aim. To assess the level of microRNA (miR) -21, -22, -126, -221 in patients with coronary artery disease (CAD) with borderline coronary artery stenosis depending on comorbidities and sex.Material and methods. We examined 37 patients with class 1-3 stable CAD aged 49-59 years with borderline (40-70%)...
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| Language: | Russian |
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«FIRMA «SILICEA» LLC
2022-11-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5224 |
| _version_ | 1797856553285451776 |
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| author | D. A. Yakhontov Yu. O. Ostanina V. V. Kononchuk L. F. Gulyaeva T. S. Kalinina E. Yu. Alekseyonok M. K. Kolyagina |
| author_facet | D. A. Yakhontov Yu. O. Ostanina V. V. Kononchuk L. F. Gulyaeva T. S. Kalinina E. Yu. Alekseyonok M. K. Kolyagina |
| author_sort | D. A. Yakhontov |
| collection | DOAJ |
| description | Aim. To assess the level of microRNA (miR) -21, -22, -126, -221 in patients with coronary artery disease (CAD) with borderline coronary artery stenosis depending on comorbidities and sex.Material and methods. We examined 37 patients with class 1-3 stable CAD aged 49-59 years with borderline (40-70%) coronary artery stenosis. The relative level of miRNA was determined using real-time polymerase chain reaction. Statistical analysis was performed using the non-parametric Mann-Whitney U-test. P<0,05 were considered statistically significant. Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007). Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology. Keywords: miRNA, obesity phenotypes, coronary artery disease, borderline coronary artery stenosis. Relationships and Activities: none. 1Novosibirsk State Medical University, Novosibirsk; 2Federal Research Center of Fundamental and Translational Medicine, Novosibirsk; 3E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia.><0,05 were considered statistically significant.Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007).Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology. |
| first_indexed | 2024-04-09T20:43:22Z |
| format | Article |
| id | doaj.art-6b9267ee7142489881c0a7cf620c3f80 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:43:22Z |
| publishDate | 2022-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-6b9267ee7142489881c0a7cf620c3f802023-03-29T21:23:42Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202022-11-01271010.15829/1560-4071-2022-52243686MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosisD. A. Yakhontov0Yu. O. Ostanina1V. V. Kononchuk2L. F. Gulyaeva3T. S. Kalinina4E. Yu. Alekseyonok5M. K. Kolyagina6Novosibirsk State Medical UniversityNovosibirsk State Medical UniversityFederal Research Center of Fundamental and Translational Medicine; E.N. Meshalkin National Medical Research CenterFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineFederal Research Center of Fundamental and Translational MedicineAim. To assess the level of microRNA (miR) -21, -22, -126, -221 in patients with coronary artery disease (CAD) with borderline coronary artery stenosis depending on comorbidities and sex.Material and methods. We examined 37 patients with class 1-3 stable CAD aged 49-59 years with borderline (40-70%) coronary artery stenosis. The relative level of miRNA was determined using real-time polymerase chain reaction. Statistical analysis was performed using the non-parametric Mann-Whitney U-test. P<0,05 were considered statistically significant. Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007). Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology. Keywords: miRNA, obesity phenotypes, coronary artery disease, borderline coronary artery stenosis. Relationships and Activities: none. 1Novosibirsk State Medical University, Novosibirsk; 2Federal Research Center of Fundamental and Translational Medicine, Novosibirsk; 3E.N. Meshalkin National Medical Research Center, Novosibirsk, Russia.><0,05 were considered statistically significant.Results. The miR-221 level was higher in the group of patients with stable CAD with borderline coronary artery stenosis with a metabolically unhealthy obesity (MUO) phenotype, but without diabetes (p=0,042). The level of miR-22 and miR-126 was higher in the group of patients with stable CAD phenotype with borderline stenosis and diabetes (p=0,007 and p=0,034, respectively). The analysis of miR levels in stable CAD patients depending on sex, without taking into account the phenotype, found that miR-21 and miR-221 values were higher in men (p=0,021 and p=0,014, respectively). The study of the sex characteristics of miR content in relation to different phenotypes revealed an increase of miR22 levels in men with MUO and diabetes (p=0,048) and an increase of miR-126 levels in women with concomitant diabetes in the comparison both with patients without MUO and diabetes (p=0,018), as well as with MUO and without diabetes (p=0,007).Conclusion. The study of the miRNA level in patients with CAD with borderline coronary artery stenosis is of great interest and reflects a promising direction in diagnosis based on comorbid pathology.https://russjcardiol.elpub.ru/jour/article/view/5224mirnaobesity phenotypescoronary artery diseaseborderline coronary artery stenosis |
| spellingShingle | D. A. Yakhontov Yu. O. Ostanina V. V. Kononchuk L. F. Gulyaeva T. S. Kalinina E. Yu. Alekseyonok M. K. Kolyagina MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis Российский кардиологический журнал mirna obesity phenotypes coronary artery disease borderline coronary artery stenosis |
| title | MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis |
| title_full | MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis |
| title_fullStr | MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis |
| title_full_unstemmed | MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis |
| title_short | MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis |
| title_sort | microrna level in patients with stable coronary artery disease with borderline coronary artery stenosis |
| topic | mirna obesity phenotypes coronary artery disease borderline coronary artery stenosis |
| url | https://russjcardiol.elpub.ru/jour/article/view/5224 |
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