Immunopathological Concepts Behind Autoimmunity
Autoimmunity is the failure of self-tolerance of an organism, which empowers immune response against its own cells and tissues generating autoimmune diseases. Autoimmune diseases are exceeding 100 million people globally. Autoimmune mechanisms underline many diseases, some are organ-specific and oth...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2018-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12143/36199_CE[Ra1]_F(SL)_PF1(A_OM)_NC(A_SHU)_PN(P).pdf |
| _version_ | 1818862895598927872 |
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| author | Soma Susan Varghese Sreenivasan Bargavan Sarojini Philips Mathew Jayan Jacob Mathew |
| author_facet | Soma Susan Varghese Sreenivasan Bargavan Sarojini Philips Mathew Jayan Jacob Mathew |
| author_sort | Soma Susan Varghese |
| collection | DOAJ |
| description | Autoimmunity is the failure of self-tolerance of an organism, which empowers immune response against its own cells and tissues generating autoimmune diseases. Autoimmune diseases are exceeding 100 million people globally. Autoimmune mechanisms underline many diseases, some are organ-specific and others are systemic in distribution. Aberrations in central and peripheral tolerance, molecular mimicry, bystander activation, cryptic antigenic and super-antigenic exposure are found to be associated with immune response against self-antigens. As the molecular biology behind autoimmune diseases is obscure, an insight on immune pathways, impaired immunity and evolution of autoimmune diseases can supplement on the therapeutic modalities of immunological diseases. |
| first_indexed | 2024-12-19T10:07:08Z |
| format | Article |
| id | doaj.art-6b937b9f2b2c40e3a4a911468e06c893 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T10:07:08Z |
| publishDate | 2018-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-6b937b9f2b2c40e3a4a911468e06c8932022-12-21T20:26:27ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-10-011210ZE01ZE0410.7860/JCDR/2018/36199.12143Immunopathological Concepts Behind AutoimmunitySoma Susan Varghese0Sreenivasan Bargavan Sarojini1Philips Mathew2Jayan Jacob Mathew3Reader, Department of Oral Pathology and Microbiology, Marbaselois Dental College, Kothamangalam, Ernakulam, Kerala, India.Professor, Department of Oral Pathology and Microbiology, Marbaselois Dental College, Kothamangalam, Ernakulam, Kerala, India.Assistant Professor, Department of Oral Medicine and Radiology, Government Dental College, Kottayam, Kerala, India.Professor, Department of Periodontics, Marbaselois Dental College, Kothamangalam, Ernakulam, Kerala, India.Autoimmunity is the failure of self-tolerance of an organism, which empowers immune response against its own cells and tissues generating autoimmune diseases. Autoimmune diseases are exceeding 100 million people globally. Autoimmune mechanisms underline many diseases, some are organ-specific and others are systemic in distribution. Aberrations in central and peripheral tolerance, molecular mimicry, bystander activation, cryptic antigenic and super-antigenic exposure are found to be associated with immune response against self-antigens. As the molecular biology behind autoimmune diseases is obscure, an insight on immune pathways, impaired immunity and evolution of autoimmune diseases can supplement on the therapeutic modalities of immunological diseases.https://jcdr.net/articles/PDF/12143/36199_CE[Ra1]_F(SL)_PF1(A_OM)_NC(A_SHU)_PN(P).pdfautoimmunitycryptic antigenepitope spreadingmolecular mimicryself tolerance |
| spellingShingle | Soma Susan Varghese Sreenivasan Bargavan Sarojini Philips Mathew Jayan Jacob Mathew Immunopathological Concepts Behind Autoimmunity Journal of Clinical and Diagnostic Research autoimmunity cryptic antigen epitope spreading molecular mimicry self tolerance |
| title | Immunopathological Concepts Behind Autoimmunity |
| title_full | Immunopathological Concepts Behind Autoimmunity |
| title_fullStr | Immunopathological Concepts Behind Autoimmunity |
| title_full_unstemmed | Immunopathological Concepts Behind Autoimmunity |
| title_short | Immunopathological Concepts Behind Autoimmunity |
| title_sort | immunopathological concepts behind autoimmunity |
| topic | autoimmunity cryptic antigen epitope spreading molecular mimicry self tolerance |
| url | https://jcdr.net/articles/PDF/12143/36199_CE[Ra1]_F(SL)_PF1(A_OM)_NC(A_SHU)_PN(P).pdf |
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