Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update
In the last few decades, the prevalence of diabetes mellitus (DM) has increased rapidly. Diabetic kidney disease (DKD) is the major cause of end-stage renal disease (ESRD) globally, attributed to hemodynamic changes and chronic hyperglycemia. Recent findings have emphasized the role of cell-cycle dy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2133 |
| _version_ | 1797624473992560640 |
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| author | Bowen Deng Anni Song Chun Zhang |
| author_facet | Bowen Deng Anni Song Chun Zhang |
| author_sort | Bowen Deng |
| collection | DOAJ |
| description | In the last few decades, the prevalence of diabetes mellitus (DM) has increased rapidly. Diabetic kidney disease (DKD) is the major cause of end-stage renal disease (ESRD) globally, attributed to hemodynamic changes and chronic hyperglycemia. Recent findings have emphasized the role of cell-cycle dysregulation in renal fibrosis and ESRD. Under normal physiological conditions, most mature renal cells are arrested in the G0 phase of the cell cycle, with a rather low rate of renewal. However, renal cells can bypass restriction points and re-enter the cell cycle under stimulation of injuries induced via metabolic disorders. Mild injuries activate proliferation of renal cells to compensate for cell loss and reinstate renal function, while severe or repeated injuries will lead to DNA damage and maladaptive repair which ultimately results in cell-cycle arrest or overproliferation, and eventually promote renal fibrosis and ESRD. In this review, we focus on the role of cell-cycle dysregulation in DKD and discuss new, emerging pathways that are implicated in the process. |
| first_indexed | 2024-03-11T09:42:51Z |
| format | Article |
| id | doaj.art-6b94698fc71747beb9ffe028940fb722 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:51Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6b94698fc71747beb9ffe028940fb7222023-11-16T16:52:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243213310.3390/ijms24032133Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An UpdateBowen Deng0Anni Song1Chun Zhang2Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaIn the last few decades, the prevalence of diabetes mellitus (DM) has increased rapidly. Diabetic kidney disease (DKD) is the major cause of end-stage renal disease (ESRD) globally, attributed to hemodynamic changes and chronic hyperglycemia. Recent findings have emphasized the role of cell-cycle dysregulation in renal fibrosis and ESRD. Under normal physiological conditions, most mature renal cells are arrested in the G0 phase of the cell cycle, with a rather low rate of renewal. However, renal cells can bypass restriction points and re-enter the cell cycle under stimulation of injuries induced via metabolic disorders. Mild injuries activate proliferation of renal cells to compensate for cell loss and reinstate renal function, while severe or repeated injuries will lead to DNA damage and maladaptive repair which ultimately results in cell-cycle arrest or overproliferation, and eventually promote renal fibrosis and ESRD. In this review, we focus on the role of cell-cycle dysregulation in DKD and discuss new, emerging pathways that are implicated in the process.https://www.mdpi.com/1422-0067/24/3/2133diabetic kidney diseaserenal fibrosiscell-cycle arrestoverproliferationinflammation |
| spellingShingle | Bowen Deng Anni Song Chun Zhang Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update International Journal of Molecular Sciences diabetic kidney disease renal fibrosis cell-cycle arrest overproliferation inflammation |
| title | Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update |
| title_full | Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update |
| title_fullStr | Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update |
| title_full_unstemmed | Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update |
| title_short | Cell-Cycle Dysregulation in the Pathogenesis of Diabetic Kidney Disease: An Update |
| title_sort | cell cycle dysregulation in the pathogenesis of diabetic kidney disease an update |
| topic | diabetic kidney disease renal fibrosis cell-cycle arrest overproliferation inflammation |
| url | https://www.mdpi.com/1422-0067/24/3/2133 |
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