Association between maternal smoking, gender, and cleft lip and palate
ABSTRACT INTRODUCTION: Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. OBJECTIVE: To assess the relationship between maternal smoking, gender and CL/P. METHODS: This is an epidemiological cross-sectional study. We interviewed 1519 mothers divided into t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-10-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500514&lng=en&tlng=en |
| _version_ | 1818954780142206976 |
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| author | Daniella Reis Barbosa Martelli Ricardo D. Coletta Eduardo A. Oliveira Mário Sérgio Oliveira Swerts Laíse A. Mendes Rodrigues Maria Christina Oliveira Hercílio Martelli Júnior |
| author_facet | Daniella Reis Barbosa Martelli Ricardo D. Coletta Eduardo A. Oliveira Mário Sérgio Oliveira Swerts Laíse A. Mendes Rodrigues Maria Christina Oliveira Hercílio Martelli Júnior |
| author_sort | Daniella Reis Barbosa Martelli |
| collection | DOAJ |
| description | ABSTRACT INTRODUCTION: Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. OBJECTIVE: To assess the relationship between maternal smoking, gender and CL/P. METHODS: This is an epidemiological cross-sectional study. We interviewed 1519 mothers divided into two groups: Cases: mothers of children with CL/P (n = 843) and Controls: mothers of children without CL/P (n = 676). All mothers were classified as smoker or non-smoker subjects during the first trimester of pregnancy. To determine an association among maternal smoking, gender, and CL/P, odds ratios were calculated and the adjustment was made by a logistic regression model. RESULTS: An association between maternal smoking and the presence of cleft was observed. There was also a strong association between male gender and the presence of cleft (OR = 3.51; 95% CI 2.83-4.37). By binary logistic regression analysis, it was demonstrated that both variables were independently associated with clefts. In a multivariate analysis, male gender and maternal smoking had a 2.5- and a 1.5-time greater chance of having a cleft, respectively. CONCLUSION: Our findings are consistent with a positive association between maternal smoking during pregnancy and CL/P in male gender. The results support the importance of smoking prevention and introduction of cessation programs among women with childbearing potential. |
| first_indexed | 2024-12-20T10:27:36Z |
| format | Article |
| id | doaj.art-6b973b48c84d4e659883c218b890f1c2 |
| institution | Directory Open Access Journal |
| issn | 1808-8686 |
| language | English |
| last_indexed | 2024-12-20T10:27:36Z |
| publishDate | 2015-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-6b973b48c84d4e659883c218b890f1c22022-12-21T19:43:47ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86862015-10-0181551451910.1016/j.bjorl.2015.07.011S1808-86942015000500514Association between maternal smoking, gender, and cleft lip and palateDaniella Reis Barbosa MartelliRicardo D. ColettaEduardo A. OliveiraMário Sérgio Oliveira SwertsLaíse A. Mendes RodriguesMaria Christina OliveiraHercílio Martelli JúniorABSTRACT INTRODUCTION: Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. OBJECTIVE: To assess the relationship between maternal smoking, gender and CL/P. METHODS: This is an epidemiological cross-sectional study. We interviewed 1519 mothers divided into two groups: Cases: mothers of children with CL/P (n = 843) and Controls: mothers of children without CL/P (n = 676). All mothers were classified as smoker or non-smoker subjects during the first trimester of pregnancy. To determine an association among maternal smoking, gender, and CL/P, odds ratios were calculated and the adjustment was made by a logistic regression model. RESULTS: An association between maternal smoking and the presence of cleft was observed. There was also a strong association between male gender and the presence of cleft (OR = 3.51; 95% CI 2.83-4.37). By binary logistic regression analysis, it was demonstrated that both variables were independently associated with clefts. In a multivariate analysis, male gender and maternal smoking had a 2.5- and a 1.5-time greater chance of having a cleft, respectively. CONCLUSION: Our findings are consistent with a positive association between maternal smoking during pregnancy and CL/P in male gender. The results support the importance of smoking prevention and introduction of cessation programs among women with childbearing potential.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500514&lng=en&tlng=enFenda labialFenda palatinaHábito de fumarGravidez |
| spellingShingle | Daniella Reis Barbosa Martelli Ricardo D. Coletta Eduardo A. Oliveira Mário Sérgio Oliveira Swerts Laíse A. Mendes Rodrigues Maria Christina Oliveira Hercílio Martelli Júnior Association between maternal smoking, gender, and cleft lip and palate Brazilian Journal of Otorhinolaryngology Fenda labial Fenda palatina Hábito de fumar Gravidez |
| title | Association between maternal smoking, gender, and cleft lip and palate |
| title_full | Association between maternal smoking, gender, and cleft lip and palate |
| title_fullStr | Association between maternal smoking, gender, and cleft lip and palate |
| title_full_unstemmed | Association between maternal smoking, gender, and cleft lip and palate |
| title_short | Association between maternal smoking, gender, and cleft lip and palate |
| title_sort | association between maternal smoking gender and cleft lip and palate |
| topic | Fenda labial Fenda palatina Hábito de fumar Gravidez |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000500514&lng=en&tlng=en |
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