Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus

Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus

We studied the neuroprotective properties of the non-competitive NMDA receptor antagonist memantine, in combination with a positive allosteric modulator of metabotropic glutamate receptors of Group III, VU 0422288. The treatment was started 48 h after the injection of neurotoxic agent trimethyltin (...

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Bibliographic Details
Main Authors: Ekaterina V. Pershina, Irina Yu. Chernomorets, Dmitry A. Fedorov, Vladimir I. Arkhipov
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
neurodegeneration
hippocampus
excitotoxicity
neuroinflammation
trimethyltin (TMT)
NMDArs
Online Access:https://www.mdpi.com/1422-0067/24/9/8249

Internet

https://www.mdpi.com/1422-0067/24/9/8249

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