Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
In this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.896469/full |
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| author | Hongbo Zhang Hongbo Zhang Yanfeng Yao Yan Li Jianjun Chen Ze Chen |
| author_facet | Hongbo Zhang Hongbo Zhang Yanfeng Yao Yan Li Jianjun Chen Ze Chen |
| author_sort | Hongbo Zhang |
| collection | DOAJ |
| description | In this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics of some viruses isolated from water samples were extremely similar to those from lakeside poultry. Pathogenic experiments showed that selected represented isolates in this study were highly pathogenic for SPF chickens but had a diversified virulence in mice. The results of our study suggested the potential transmission of avian influenza (H5N1) between the poultry and wild waterfowls and water body around the habitat may play an important role. |
| first_indexed | 2024-04-12T17:26:17Z |
| format | Article |
| id | doaj.art-6b9bfbc88fd54ddc927ec5f5b036992a |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T17:26:17Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-6b9bfbc88fd54ddc927ec5f5b036992a2022-12-22T03:23:18ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-05-011310.3389/fmicb.2022.896469896469Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 VirusesHongbo Zhang0Hongbo Zhang1Yanfeng Yao2Yan Li3Jianjun Chen4Ze Chen5State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaLouisiana State University Health Sciences Center, Shreveport, LA, United StatesState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaIn this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics of some viruses isolated from water samples were extremely similar to those from lakeside poultry. Pathogenic experiments showed that selected represented isolates in this study were highly pathogenic for SPF chickens but had a diversified virulence in mice. The results of our study suggested the potential transmission of avian influenza (H5N1) between the poultry and wild waterfowls and water body around the habitat may play an important role.https://www.frontiersin.org/articles/10.3389/fmicb.2022.896469/fullDongting Lakewater-borneHPAIV H5N1genotypingphylogenetic analysis |
| spellingShingle | Hongbo Zhang Hongbo Zhang Yanfeng Yao Yan Li Jianjun Chen Ze Chen Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses Frontiers in Microbiology Dongting Lake water-borne HPAIV H5N1 genotyping phylogenetic analysis |
| title | Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses |
| title_full | Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses |
| title_fullStr | Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses |
| title_full_unstemmed | Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses |
| title_short | Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses |
| title_sort | evidence for water borne transmission of highly pathogenic avian influenza h5n1 viruses |
| topic | Dongting Lake water-borne HPAIV H5N1 genotyping phylogenetic analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.896469/full |
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