Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

INTRODUCTION: Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast...

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Bibliographic Details
Main Authors: Marica Vaapil, Karolina Helczynska, René Villadsen, Ole W Petersen, Elisabet Johansson, Siv Beckman, Christer Larsson, Sven Påhlman, Annika Jögi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3460905?pdf=render

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