Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case

Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case

A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and t...

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Main Authors: Kevin M. Vannella, Cihan Oguz, Sydney R. Stein, Stefania Pittaluga, Esra Dikoglu, Arjun Kanwal, Sabrina C. Ramelli, Thomas Briese, Ling Su, Xiaolin Wu, Marcos J. Ramos-Benitez, Luis J. Perez-Valencia, Ashley Babyak, Nu Ri Cha, Joon-Yong Chung, Kris Ylaya, Ronson J. Madathil, Kapil K. Saharia, Thomas M. Scalea, Quincy K. Tran, Daniel L. Herr, David E. Kleiner, Stephen M. Hewitt, Luigi D. Notarangelo, Alison Grazioli, Daniel S. Chertow
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
MIS-A
myocarditis
SARS-CoV-2
T cell receptor (TCR)
SARS-CoV-2 epitopes
CDR3 sequences
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.779026/full

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