Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis
Abstract The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from lack of interpretability. Here, we present a deep...
Main Authors: | Erik Hartman, Aaron M. Scott, Christofer Karlsson, Tirthankar Mohanty, Suvi T. Vaara, Adam Linder, Lars Malmström, Johan Malmström |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-41146-4 |
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