Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/13/20/4471 |
| _version_ | 1797551484114567168 |
|---|---|
| author | Francesca Posa Adriana Di Benedetto Giampietro Ravagnan Elisabetta Ada Cavalcanti-Adam Lorenzo Lo Muzio Gianluca Percoco Giorgio Mori |
| author_facet | Francesca Posa Adriana Di Benedetto Giampietro Ravagnan Elisabetta Ada Cavalcanti-Adam Lorenzo Lo Muzio Gianluca Percoco Giorgio Mori |
| author_sort | Francesca Posa |
| collection | DOAJ |
| description | Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes. |
| first_indexed | 2024-03-10T15:45:45Z |
| format | Article |
| id | doaj.art-6ba2eb818da94d43a142fdb19c7353b5 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T15:45:45Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-6ba2eb818da94d43a142fdb19c7353b52023-11-20T16:28:29ZengMDPI AGMaterials1996-19442020-10-011320447110.3390/ma13204471Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of OligostilbenesFrancesca Posa0Adriana Di Benedetto1Giampietro Ravagnan2Elisabetta Ada Cavalcanti-Adam3Lorenzo Lo Muzio4Gianluca Percoco5Giorgio Mori6Department of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyGlures srl. Unità Operativa di Napoli, Spin off Accademico dell’Università di Venezia Cà Foscari, Via delle Industrie 19b-30175 Venezia, ItalyDepartment of Biophysical Chemistry, Heidelberg University and Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, GermanyDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Mechanics, Mathematics and Management, Polytechnic University of Bari, Via E. Orabona 4, 70125 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDiseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.https://www.mdpi.com/1996-1944/13/20/4471bonemesenchymal stem cellsbiomaterialpolycarbonateresveratrolpolydatin |
| spellingShingle | Francesca Posa Adriana Di Benedetto Giampietro Ravagnan Elisabetta Ada Cavalcanti-Adam Lorenzo Lo Muzio Gianluca Percoco Giorgio Mori Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes Materials bone mesenchymal stem cells biomaterial polycarbonate resveratrol polydatin |
| title | Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes |
| title_full | Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes |
| title_fullStr | Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes |
| title_full_unstemmed | Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes |
| title_short | Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes |
| title_sort | bioengineering bone tissue with 3d printed scaffolds in the presence of oligostilbenes |
| topic | bone mesenchymal stem cells biomaterial polycarbonate resveratrol polydatin |
| url | https://www.mdpi.com/1996-1944/13/20/4471 |
| work_keys_str_mv | AT francescaposa bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes AT adrianadibenedetto bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes AT giampietroravagnan bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes AT elisabettaadacavalcantiadam bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes AT lorenzolomuzio bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes AT gianlucapercoco bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes AT giorgiomori bioengineeringbonetissuewith3dprintedscaffoldsinthepresenceofoligostilbenes |