Association between frailty and ischemic heart disease: a systematic review and meta-analysis
Abstract Background Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic hear...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-021-02304-9 |
| _version_ | 1828146840435949568 |
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| author | Rosa Liperoti Davide L. Vetrano Katie Palmer Tomasz Targowski Maria C. Cipriani Maria R. Lo Monaco Silvia Giovannini Nicola Acampora Emanuele Rocco Villani Roberto Bernabei Graziano Onder on behalf of ADVANTAGE JA WP4 group |
| author_facet | Rosa Liperoti Davide L. Vetrano Katie Palmer Tomasz Targowski Maria C. Cipriani Maria R. Lo Monaco Silvia Giovannini Nicola Acampora Emanuele Rocco Villani Roberto Bernabei Graziano Onder on behalf of ADVANTAGE JA WP4 group |
| author_sort | Rosa Liperoti |
| collection | DOAJ |
| description | Abstract Background Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic heart disease (IHD). We performed a systematic review of literature and a meta-analysis to assess the association between frailty and IHD. Methods We selected all the studies that provided information on the association between frailty and IHD, regardless of the study setting, study design, or definition of IHD and frailty. PubMed, Web of Science and Embase were searched for relevant papers. Studies that adopted the Fried definition for frailty were included in the meta-analyses. For each measure of interest (proportions and estimates of associations), a meta-analysis was performed if at least three studies used the same definition of frailty. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Results Thirty-seven studies were included. Of these, 22 adopted the Fried criteria to define frailty and provided estimates of prevalence and therefore they were included in meta-analyses. The pooled prevalence of IHD in frail individuals was 17% (95% Confidence Interval [95%CI] 11–23%) and the pooled prevalence of frailty in individuals with IHD was 19% (95% CI 15–24%). The prevalence of frailty among IHD patients ranged from 4 to 61%. Insufficient data were found to assess longitudinal association between frailty and IHD. Conclusions Frailty is quite common in older persons with IHD. The identification of frailty among older adults with IHD should be considered relevant to provide individualized strategies of cardiovascular prevention and care. Further research should specifically explore the association between frailty and IHD and investigate the potential common biological ground. |
| first_indexed | 2024-04-11T20:51:57Z |
| format | Article |
| id | doaj.art-6ba40ab399ff4dcead51d105fc93904a |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-11T20:51:57Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-6ba40ab399ff4dcead51d105fc93904a2022-12-22T04:03:49ZengBMCBMC Geriatrics1471-23182021-06-012111910.1186/s12877-021-02304-9Association between frailty and ischemic heart disease: a systematic review and meta-analysisRosa Liperoti0Davide L. Vetrano1Katie Palmer2Tomasz Targowski3Maria C. Cipriani4Maria R. Lo Monaco5Silvia Giovannini6Nicola Acampora7Emanuele Rocco Villani8Roberto Bernabei9Graziano Onder10on behalf of ADVANTAGE JA WP4 groupUniversità Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCSAging Research Center, Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet and Stockholm UniversityUniversità Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Geriatrics, National Institute of Geriatrics, Rheumatology, and RehabilitationFondazione Policlinico Universitario A. Gemelli IRCCSFondazione Policlinico Universitario A. Gemelli IRCCSFondazione Policlinico Universitario A. Gemelli IRCCSFondazione Policlinico Universitario A. Gemelli IRCCSUniversità Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCSUniversità Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCSIstituto Superiore di SanitàAbstract Background Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic heart disease (IHD). We performed a systematic review of literature and a meta-analysis to assess the association between frailty and IHD. Methods We selected all the studies that provided information on the association between frailty and IHD, regardless of the study setting, study design, or definition of IHD and frailty. PubMed, Web of Science and Embase were searched for relevant papers. Studies that adopted the Fried definition for frailty were included in the meta-analyses. For each measure of interest (proportions and estimates of associations), a meta-analysis was performed if at least three studies used the same definition of frailty. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Results Thirty-seven studies were included. Of these, 22 adopted the Fried criteria to define frailty and provided estimates of prevalence and therefore they were included in meta-analyses. The pooled prevalence of IHD in frail individuals was 17% (95% Confidence Interval [95%CI] 11–23%) and the pooled prevalence of frailty in individuals with IHD was 19% (95% CI 15–24%). The prevalence of frailty among IHD patients ranged from 4 to 61%. Insufficient data were found to assess longitudinal association between frailty and IHD. Conclusions Frailty is quite common in older persons with IHD. The identification of frailty among older adults with IHD should be considered relevant to provide individualized strategies of cardiovascular prevention and care. Further research should specifically explore the association between frailty and IHD and investigate the potential common biological ground.https://doi.org/10.1186/s12877-021-02304-9FrailtyIschemic heart diseaseSystematic reviewMetanalysis |
| spellingShingle | Rosa Liperoti Davide L. Vetrano Katie Palmer Tomasz Targowski Maria C. Cipriani Maria R. Lo Monaco Silvia Giovannini Nicola Acampora Emanuele Rocco Villani Roberto Bernabei Graziano Onder on behalf of ADVANTAGE JA WP4 group Association between frailty and ischemic heart disease: a systematic review and meta-analysis BMC Geriatrics Frailty Ischemic heart disease Systematic review Metanalysis |
| title | Association between frailty and ischemic heart disease: a systematic review and meta-analysis |
| title_full | Association between frailty and ischemic heart disease: a systematic review and meta-analysis |
| title_fullStr | Association between frailty and ischemic heart disease: a systematic review and meta-analysis |
| title_full_unstemmed | Association between frailty and ischemic heart disease: a systematic review and meta-analysis |
| title_short | Association between frailty and ischemic heart disease: a systematic review and meta-analysis |
| title_sort | association between frailty and ischemic heart disease a systematic review and meta analysis |
| topic | Frailty Ischemic heart disease Systematic review Metanalysis |
| url | https://doi.org/10.1186/s12877-021-02304-9 |
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