Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation
Purpose: The goal of the study was to highlight the added value of 18-F-FDG PET/CT over isolated CT to depict pancreatic tumors, distant metastases, monitor response to treatment and its usefulness in distinguishing fibrosis from residual/recurrence, thus direct biopsy to sites more likely to yield...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X16301115 |
| _version_ | 1819088320653688832 |
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| author | Ekhlas Abdelmonem Ibrahem Nasr Shaban |
| author_facet | Ekhlas Abdelmonem Ibrahem Nasr Shaban |
| author_sort | Ekhlas Abdelmonem Ibrahem Nasr Shaban |
| collection | DOAJ |
| description | Purpose: The goal of the study was to highlight the added value of 18-F-FDG PET/CT over isolated CT to depict pancreatic tumors, distant metastases, monitor response to treatment and its usefulness in distinguishing fibrosis from residual/recurrence, thus direct biopsy to sites more likely to yield representative tumor tissue.
Patients and methods: This study included 20 patients for which 18-F-PET/CT scans were performed. A case based analysis was performed in detailed manner for lesions on CT and fused images of 18-F-PET/CT. Statistical analysis including specificity, Sensitivity, negative predictive value (NPV) and positive predictive value (PPV) of each of these modalities was performed. A final diagnosis of metastasis was confirmed by further clinical and radiological workup.
Results: PET/CT has 100% sensitivity, 88.9% specificity, 91.7% PPV, 100% NPV and 95% accuracy compared to 77.8% sensitivity and 54.5% specificity, 58.3% PPV, 75% NPV and 65% accuracy for CT in diagnosis and monitoring treatment response.
Conclusion: Combined 18-F FDG PET/CT significantly improves the sensitivity and specificity of isolated CT for depicting pancreatic tumors, distant metastases, monitor response to treatment distinguishing fibrosis from residual/recurrence. |
| first_indexed | 2024-12-21T21:50:10Z |
| format | Article |
| id | doaj.art-6ba496fd019a4b1d9918ca7bada3b780 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-21T21:50:10Z |
| publishDate | 2016-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-6ba496fd019a4b1d9918ca7bada3b7802022-12-21T18:49:07ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-12-014741275128210.1016/j.ejrnm.2016.07.007Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observationEkhlas Abdelmonem Ibrahem Nasr ShabanPurpose: The goal of the study was to highlight the added value of 18-F-FDG PET/CT over isolated CT to depict pancreatic tumors, distant metastases, monitor response to treatment and its usefulness in distinguishing fibrosis from residual/recurrence, thus direct biopsy to sites more likely to yield representative tumor tissue. Patients and methods: This study included 20 patients for which 18-F-PET/CT scans were performed. A case based analysis was performed in detailed manner for lesions on CT and fused images of 18-F-PET/CT. Statistical analysis including specificity, Sensitivity, negative predictive value (NPV) and positive predictive value (PPV) of each of these modalities was performed. A final diagnosis of metastasis was confirmed by further clinical and radiological workup. Results: PET/CT has 100% sensitivity, 88.9% specificity, 91.7% PPV, 100% NPV and 95% accuracy compared to 77.8% sensitivity and 54.5% specificity, 58.3% PPV, 75% NPV and 65% accuracy for CT in diagnosis and monitoring treatment response. Conclusion: Combined 18-F FDG PET/CT significantly improves the sensitivity and specificity of isolated CT for depicting pancreatic tumors, distant metastases, monitor response to treatment distinguishing fibrosis from residual/recurrence.http://www.sciencedirect.com/science/article/pii/S0378603X16301115CT18-F-FDG PET/CTPancreatic cancer |
| spellingShingle | Ekhlas Abdelmonem Ibrahem Nasr Shaban Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation The Egyptian Journal of Radiology and Nuclear Medicine CT 18-F-FDG PET/CT Pancreatic cancer |
| title | Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation |
| title_full | Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation |
| title_fullStr | Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation |
| title_full_unstemmed | Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation |
| title_short | Added value of 18-F-FDG-PET/CT in patients with pancreatic cancer: Initial observation |
| title_sort | added value of 18 f fdg pet ct in patients with pancreatic cancer initial observation |
| topic | CT 18-F-FDG PET/CT Pancreatic cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X16301115 |
| work_keys_str_mv | AT ekhlasabdelmonemibrahemnasrshaban addedvalueof18ffdgpetctinpatientswithpancreaticcancerinitialobservation |