An Activation-Specific Anti-Mac-1 Designed-Ankyrin-Repeat-Protein Attenuates Colitis in Mice

An Activation-Specific Anti-Mac-1 Designed-Ankyrin-Repeat-Protein Attenuates Colitis in Mice

(1) Background: Inflammatory bowel diseases are complex and multifactorial disorders of unknown etiology. The extravasation of activated leukocytes is a critical step in the pathogenesis of these diseases. Leukocyte integrin Mac-1 (α<sub>M</sub>β<sub>2</sub>; CD11b/CD18) is c...

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Bibliographic Details
Main Authors: Istvan Bojti, Qianqi Wang, Tibor Bojti, Felicitas Bojti, Patrick Malcolm Siegel, Timo Heidt, Martin Moser, Christoph Bode, Dirk Westermann, Karlheinz Peter, Philipp Diehl
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Life
Subjects:
inflammatory bowel diseases
colitis
DARPin
Mac-1
therapy
DSS
Online Access:https://www.mdpi.com/2075-1729/13/7/1464

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