Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration
Endoplasmic reticulum stress (ERS) is a kind of cell response for coping with hypoxia and other stresses. Pieces of evidence show that continuous stress can promote the occurrence, development, and drug resistance of tumors through the unfolded protein response. Therefore, the abnormal ac-tivation o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1273987/full |
| _version_ | 1797681796559667200 |
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| author | Bowen Qing Song Wang Yingan Du Can Liu Wei Li |
| author_facet | Bowen Qing Song Wang Yingan Du Can Liu Wei Li |
| author_sort | Bowen Qing |
| collection | DOAJ |
| description | Endoplasmic reticulum stress (ERS) is a kind of cell response for coping with hypoxia and other stresses. Pieces of evidence show that continuous stress can promote the occurrence, development, and drug resistance of tumors through the unfolded protein response. Therefore, the abnormal ac-tivation of ERS and its downstream signaling pathways not only can regulate tumor growth and metastasis but also profoundly affect the efficacy of antitumor therapy. Therefore, revealing the molecular mechanism of ERS may be expected to solve the problem of tumor multidrug resistance (MDR) and become a novel strategy for the treatment of refractory and recurrent tumors. This re-view summarized the mechanism of ERS and tumor MDR, reviewed the relationship between ERS and tumor MDR, introduced the research status of tumor tissue and ERS, and previewed the prospect of targeting ERS to improve the therapeutic effect of tumor MDR. This article aims to provide researchers and clinicians with new ideas and inspiration for basic antitumor treatment. |
| first_indexed | 2024-03-11T23:50:13Z |
| format | Article |
| id | doaj.art-6ba7f93607954186b9c0865a32279bda |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T23:50:13Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-6ba7f93607954186b9c0865a32279bda2023-09-19T07:36:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-09-011410.3389/fphar.2023.12739871273987Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustrationBowen Qing0Song Wang1Yingan Du2Can Liu3Wei Li4First Affiliated Hospital of Hunan Normal University, Department of Hematology, Hunan Provincial People’s Hospital, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaFirst Affiliated Hospital of Hunan Normal University, Department of Hematology, Hunan Provincial People’s Hospital, Changsha, ChinaFirst Affiliated Hospital of Hunan Normal University, Department of Hematology, Hunan Provincial People’s Hospital, Changsha, ChinaFirst Affiliated Hospital of Hunan Normal University, Department of Hematology, Hunan Provincial People’s Hospital, Changsha, ChinaEndoplasmic reticulum stress (ERS) is a kind of cell response for coping with hypoxia and other stresses. Pieces of evidence show that continuous stress can promote the occurrence, development, and drug resistance of tumors through the unfolded protein response. Therefore, the abnormal ac-tivation of ERS and its downstream signaling pathways not only can regulate tumor growth and metastasis but also profoundly affect the efficacy of antitumor therapy. Therefore, revealing the molecular mechanism of ERS may be expected to solve the problem of tumor multidrug resistance (MDR) and become a novel strategy for the treatment of refractory and recurrent tumors. This re-view summarized the mechanism of ERS and tumor MDR, reviewed the relationship between ERS and tumor MDR, introduced the research status of tumor tissue and ERS, and previewed the prospect of targeting ERS to improve the therapeutic effect of tumor MDR. This article aims to provide researchers and clinicians with new ideas and inspiration for basic antitumor treatment.https://www.frontiersin.org/articles/10.3389/fphar.2023.1273987/fullendoplasmic reticulum stressunfolded protein responsemultidrug resistanceapoptosismolecular mechanism |
| spellingShingle | Bowen Qing Song Wang Yingan Du Can Liu Wei Li Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration Frontiers in Pharmacology endoplasmic reticulum stress unfolded protein response multidrug resistance apoptosis molecular mechanism |
| title | Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration |
| title_full | Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration |
| title_fullStr | Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration |
| title_full_unstemmed | Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration |
| title_short | Crosstalk between endoplasmic reticulum stress and multidrug-resistant cancers: hope or frustration |
| title_sort | crosstalk between endoplasmic reticulum stress and multidrug resistant cancers hope or frustration |
| topic | endoplasmic reticulum stress unfolded protein response multidrug resistance apoptosis molecular mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1273987/full |
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