Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein
Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged m...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2023-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100883&tlng=en |
| _version_ | 1797951312645586944 |
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| author | Jomkarn Naphatthalung Pilaipan Chairuk Somruedee Yorsin Kanyanatt Kanokwiroon Nisaudah Radenahmad Chaweewan Jansakul |
| author_facet | Jomkarn Naphatthalung Pilaipan Chairuk Somruedee Yorsin Kanyanatt Kanokwiroon Nisaudah Radenahmad Chaweewan Jansakul |
| author_sort | Jomkarn Naphatthalung |
| collection | DOAJ |
| description | Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats. |
| first_indexed | 2024-04-10T22:29:40Z |
| format | Article |
| id | doaj.art-6ba81f1f8fdf489b8009b308e655db91 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-10T22:29:40Z |
| publishDate | 2023-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-6ba81f1f8fdf489b8009b308e655db912023-01-17T07:34:17ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-01-015810.1590/s2175-97902022e20510Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk proteinJomkarn NaphatthalungPilaipan ChairukSomruedee YorsinKanyanatt KanokwiroonNisaudah RadenahmadChaweewan Jansakulhttps://orcid.org/0000-0002-5703-3677Abstract We investigated whether coconut milk protein (CMP) contributes to the beneficial effects of coconut milk consumption on cardiovascular health markers previously found in middle-aged rats. CMP was isolated and precipitated from dried fresh coconut milk, then gavaged (1 g/kg) to middle-aged male rats for six weeks; control rats received distilled water. Compared to controls, CMP caused decreased body fat and lipid accumulation in liver cells and the platelet count. CMP did not affect basal blood pressure or heart rate in anesthetized rats. Vascular responsiveness to phenylephrine, DL-propargylglycine (PAG), acetylcholine or sodium nitroprusside was unaffected, but vasorelaxation to glyceryl trinitrate (GTN) increased. Effects of ODQ on vasorelaxation to GTN were similar in both groups. Expression of blood vessel eNOS, CSE and sGC was normal. The cyclic guanosine monophosphate (cGMP) level of CMP-treated rats was normal but addition of GTN increased cGMP and NO concentration more in CMP-treated rats than in controls, an effect unaltered by addition of diadzin. Taken together, CMP appears partially responsible for the improvement in cardiovascular health markers caused by coconut milk in middle-aged male rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100883&tlng=enCoconut proteinBlood vesselLiver lipidNOGlyceryl trinitrate |
| spellingShingle | Jomkarn Naphatthalung Pilaipan Chairuk Somruedee Yorsin Kanyanatt Kanokwiroon Nisaudah Radenahmad Chaweewan Jansakul Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein Brazilian Journal of Pharmaceutical Sciences Coconut protein Blood vessel Liver lipid NO Glyceryl trinitrate |
| title | Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein |
| title_full | Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein |
| title_fullStr | Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein |
| title_full_unstemmed | Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein |
| title_short | Decreased body-fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle-aged male rats following six-weeks consumption of coconut milk protein |
| title_sort | decreased body fat accumulation and increased vasorelaxation to glyceryl trinitrate in middle aged male rats following six weeks consumption of coconut milk protein |
| topic | Coconut protein Blood vessel Liver lipid NO Glyceryl trinitrate |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100883&tlng=en |
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