Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling pathways

Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling pathways

Abstract Neddylation is a post-translational modification process, similar to ubiquitination, that controls several biological processes. Notably, it is often aberrantly activated in neoplasms and plays a critical role in the intricate dynamics of the tumor microenvironment (TME). This regulatory in...

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Bibliographic Details
Main Authors: Dequan Liu, Xiangyu Che, Guangzhen Wu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Biomarker Research
Subjects:
Neddylation
TME
NEDD8
Signaling pathway
MLN4924
Clinical trials
Online Access:https://doi.org/10.1186/s40364-023-00545-x

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