Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

<p>Abstract</p> <p>Background</p> <p>Accumulation of aberrant proteins to form Lewy bodies (LBs) is a hallmark of Parkinson's disease (PD). Ubiquitination-mediated degradation of aberrant, misfolded proteins is critical for maintaining normal cell function. Emergin...

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Bibliographic Details
Main Authors:	Ma Yuliang, Reicher Joshua, Wu Wei, Kabakoff Jonathan, Shi Yang, Yao Dongdong, Meng Fanjun, Moosmann Bernd, Masliah Eliezer, Lipton Stuart A, Gu Zezong
Format:	Article
Language:	English
Published:	BMC 2011-05-01
Series:	Molecular Neurodegeneration
Online Access:	http://www.molecularneurodegeneration.com/content/6/1/34

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