Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus.

Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus.

Omega-3 fatty acid (n-3 FA) deficiency is an environmental risk factor for schizophrenia, yet characterisation of the consequences of deficiency at the protein level in the brain is limited. We aimed to identify the protein pathways disrupted as a consequence of chronic n-3 deficiency in the hippoc...

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Bibliographic Details
Main Authors: Jane A English, Akiko eHarauma, Melanie eFöcking, Kieran eWynne, Caitriona eScaife, Gerard eCagney, Toru eMoriguchi, David R Cotter
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Genetics
Subjects:
Proteomics
Schizophrenia
neuritogenesis
Mitochondrial dysfunction
Omega-3 fatty Acids
Clathrin Mediated Endocytisis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00208/full
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Summary:Omega-3 fatty acid (n-3 FA) deficiency is an environmental risk factor for schizophrenia, yet characterisation of the consequences of deficiency at the protein level in the brain is limited. We aimed to identify the protein pathways disrupted as a consequence of chronic n-3 deficiency in the hippocampus of mice. Fatty acid analysis of the hippocampus following chronic dietary deficiency revealed a 3-fold decrease (p
ISSN:1664-8021

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