Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus.
Omega-3 fatty acid (n-3 FA) deficiency is an environmental risk factor for schizophrenia, yet characterisation of the consequences of deficiency at the protein level in the brain is limited. We aimed to identify the protein pathways disrupted as a consequence of chronic n-3 deficiency in the hippoc...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-10-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00208/full |
| _version_ | 1819062059264901120 |
|---|---|
| author | Jane A English Jane A English Akiko eHarauma Melanie eFöcking Kieran eWynne Caitriona eScaife Gerard eCagney Toru eMoriguchi David R Cotter |
| author_facet | Jane A English Jane A English Akiko eHarauma Melanie eFöcking Kieran eWynne Caitriona eScaife Gerard eCagney Toru eMoriguchi David R Cotter |
| author_sort | Jane A English |
| collection | DOAJ |
| description | Omega-3 fatty acid (n-3 FA) deficiency is an environmental risk factor for schizophrenia, yet characterisation of the consequences of deficiency at the protein level in the brain is limited. We aimed to identify the protein pathways disrupted as a consequence of chronic n-3 deficiency in the hippocampus of mice. Fatty acid analysis of the hippocampus following chronic dietary deficiency revealed a 3-fold decrease (p |
| first_indexed | 2024-12-21T14:52:45Z |
| format | Article |
| id | doaj.art-6bb07268faca4ee58ec8fe2bf39ceb42 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-21T14:52:45Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6bb07268faca4ee58ec8fe2bf39ceb422022-12-21T18:59:50ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-10-01410.3389/fgene.2013.0020863730Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus.Jane A English0Jane A English1Akiko eHarauma2Melanie eFöcking3Kieran eWynne4Caitriona eScaife5Gerard eCagney6Toru eMoriguchi7David R Cotter8Royal College of Surgeons in IrelandUniversity College DublinAzabu UniversityRoyal College of Surgeons in IrelandUniversity College DublinUniversity College DublinUniversity College DublinAzabu UniversityRoyal College of Surgeons in IrelandOmega-3 fatty acid (n-3 FA) deficiency is an environmental risk factor for schizophrenia, yet characterisation of the consequences of deficiency at the protein level in the brain is limited. We aimed to identify the protein pathways disrupted as a consequence of chronic n-3 deficiency in the hippocampus of mice. Fatty acid analysis of the hippocampus following chronic dietary deficiency revealed a 3-fold decrease (phttp://journal.frontiersin.org/Journal/10.3389/fgene.2013.00208/fullProteomicsSchizophrenianeuritogenesisMitochondrial dysfunctionOmega-3 fatty AcidsClathrin Mediated Endocytisis |
| spellingShingle | Jane A English Jane A English Akiko eHarauma Melanie eFöcking Kieran eWynne Caitriona eScaife Gerard eCagney Toru eMoriguchi David R Cotter Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus. Frontiers in Genetics Proteomics Schizophrenia neuritogenesis Mitochondrial dysfunction Omega-3 fatty Acids Clathrin Mediated Endocytisis |
| title | Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus. |
| title_full | Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus. |
| title_fullStr | Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus. |
| title_full_unstemmed | Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus. |
| title_short | Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus. |
| title_sort | omega 3 fatty acid deficiency disrupts endocytosis neuritogenesis and mitochondrial protein pathways in the mouse hippocampus |
| topic | Proteomics Schizophrenia neuritogenesis Mitochondrial dysfunction Omega-3 fatty Acids Clathrin Mediated Endocytisis |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00208/full |
| work_keys_str_mv | AT janeaenglish omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT janeaenglish omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT akikoeharauma omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT melanieefocking omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT kieranewynne omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT caitrionaescaife omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT gerardecagney omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT toruemoriguchi omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus AT davidrcotter omega3fattyaciddeficiencydisruptsendocytosisneuritogenesisandmitochondrialproteinpathwaysinthemousehippocampus |