Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature
Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs. Nowadays, due to restrictive health resources, the question arises whether routine pharmacogenetic analyses...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00189/full |
| _version_ | 1828283379546587136 |
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| author | Nemanja Rancic Viktorija Dragojevic-Simic Neven Vavić Aleksandra Kovacevic Zoran Segrt Natasa Djordjevic |
| author_facet | Nemanja Rancic Viktorija Dragojevic-Simic Neven Vavić Aleksandra Kovacevic Zoran Segrt Natasa Djordjevic |
| author_sort | Nemanja Rancic |
| collection | DOAJ |
| description | Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs. Nowadays, due to restrictive health resources, the question arises whether routine pharmacogenetic analyses should be done in the renal transplant recipients or not. The aim of this literature review was to present the up-to-date information considering the economic feasibility of pharmacogenetic testing in patients subjected to renal transplantation. The organization United Network for Organ Sharing in the United States estimated that total costs per renal transplant concerning these analyses were $334,300 in 2014. Pharmacogenetic testing prior to treatment initiation could be helpful to predict and assess treatment response and the risks for adverse drug reactions. This kind of testing before treatment initiation seems to be one of the most promising applications of pharmacokinetics. Although pharmacogenetic tests were found to be a cost-effective or cost-saving strategy in many cases, some authors represent another opinion. However, if the real costs of renal transplantation are recognized, the application of these tests in the standard daily practice could be considered more realistic, which additionally emphasizes the importance of future studies assessing their cost-effectiveness. |
| first_indexed | 2024-04-13T08:44:19Z |
| format | Article |
| id | doaj.art-6bb0e0edaa804d43b950297432298775 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T08:44:19Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-6bb0e0edaa804d43b9502974322987752022-12-22T02:53:46ZengFrontiers Media S.A.Frontiers in Public Health2296-25652016-08-01410.3389/fpubh.2016.00189217965Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literatureNemanja Rancic0Viktorija Dragojevic-Simic1Neven Vavić2Aleksandra Kovacevic3Zoran Segrt4Natasa Djordjevic5Medical Faculty Military Medical Academy, University of DefenceMedical Faculty Military Medical Academy, University of DefenceMilitary Medical AcademyMedical Faculty Military Medical Academy, University of DefenceMilitary Medical Academy Medical Faculty, University of DefenceThe Faculty of Medical Sciences, University of KragujevacRenal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs. Nowadays, due to restrictive health resources, the question arises whether routine pharmacogenetic analyses should be done in the renal transplant recipients or not. The aim of this literature review was to present the up-to-date information considering the economic feasibility of pharmacogenetic testing in patients subjected to renal transplantation. The organization United Network for Organ Sharing in the United States estimated that total costs per renal transplant concerning these analyses were $334,300 in 2014. Pharmacogenetic testing prior to treatment initiation could be helpful to predict and assess treatment response and the risks for adverse drug reactions. This kind of testing before treatment initiation seems to be one of the most promising applications of pharmacokinetics. Although pharmacogenetic tests were found to be a cost-effective or cost-saving strategy in many cases, some authors represent another opinion. However, if the real costs of renal transplantation are recognized, the application of these tests in the standard daily practice could be considered more realistic, which additionally emphasizes the importance of future studies assessing their cost-effectiveness.http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00189/fullHealth EconomicsRenal transplantationGenetic polymorphismsimmunosuppressive drugsPharmacogenetic tests |
| spellingShingle | Nemanja Rancic Viktorija Dragojevic-Simic Neven Vavić Aleksandra Kovacevic Zoran Segrt Natasa Djordjevic Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature Frontiers in Public Health Health Economics Renal transplantation Genetic polymorphisms immunosuppressive drugs Pharmacogenetic tests |
| title | Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature |
| title_full | Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature |
| title_fullStr | Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature |
| title_full_unstemmed | Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature |
| title_short | Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: a review of literature |
| title_sort | economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation a review of literature |
| topic | Health Economics Renal transplantation Genetic polymorphisms immunosuppressive drugs Pharmacogenetic tests |
| url | http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00189/full |
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