Vaccines in Children with Inflammatory Bowel Disease: Brief Review
Incidence of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing worldwide. Children with IBDs have a dysfunctional immune system and they are frequently treated with immunomodulating drugs and biological therapy, which significantly impair i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/5/487 |
| _version_ | 1797534662698991616 |
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| author | Susanna Esposito Giulia Antoniol Marialuisa Labate Lucrezia Passadore Patrizia Alvisi Valeria Daccò Chiara Ghizzi Carla Colombo Nicola Principi |
| author_facet | Susanna Esposito Giulia Antoniol Marialuisa Labate Lucrezia Passadore Patrizia Alvisi Valeria Daccò Chiara Ghizzi Carla Colombo Nicola Principi |
| author_sort | Susanna Esposito |
| collection | DOAJ |
| description | Incidence of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing worldwide. Children with IBDs have a dysfunctional immune system and they are frequently treated with immunomodulating drugs and biological therapy, which significantly impair immune system functions and lead to an increased risk of infections. Vaccines are essential to prevent at least part of these infections and this explains why strict compliance to the immunization guidelines specifically prepared for IBD patients is strongly recommended. However, several factors might lead to insufficient immunization. In this paper, present knowledge on the use of vaccines in children with IBDs is discussed. Literature review showed that despite a lack of detailed quantification of the risk of infections in children with IBDs, these children might have infections more frequently than age-matched healthy subjects, and at least in some cases, these infections might be even more severe. Fortunately, most of these infections could be prevented when recommended schedules of immunization are carefully followed. Vaccines given to children with IBDs generally have adequate immunogenicity and safety. Attention must be paid to live attenuated vaccines that can be administered only to children without or with mild immune system function impairment. Vaccination of their caregivers is also recommended. Unfortunately, compliance to these recommendations is generally low and multidisciplinary educational programs to improve vaccination coverage must be planned, in order to protect children with IBD from vaccine-preventable diseases. |
| first_indexed | 2024-03-10T11:33:41Z |
| format | Article |
| id | doaj.art-6bb39f391f254d13b33992d2484c365b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T11:33:41Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6bb39f391f254d13b33992d2484c365b2023-11-21T19:04:40ZengMDPI AGVaccines2076-393X2021-05-019548710.3390/vaccines9050487Vaccines in Children with Inflammatory Bowel Disease: Brief ReviewSusanna Esposito0Giulia Antoniol1Marialuisa Labate2Lucrezia Passadore3Patrizia Alvisi4Valeria Daccò5Chiara Ghizzi6Carla Colombo7Nicola Principi8Paediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPaediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPaediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPaediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPediatric Gastroenterology Unit, Maggiore Hospital, 40133 Bologna, ItalyCystic Fibrosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, ItalyPediatric Unit, Maggiore Hospital, 40133 Bologna, ItalyCystic Fibrosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, ItalyUniversità degli Studi di Milano, 20122 Milan, ItalyIncidence of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing worldwide. Children with IBDs have a dysfunctional immune system and they are frequently treated with immunomodulating drugs and biological therapy, which significantly impair immune system functions and lead to an increased risk of infections. Vaccines are essential to prevent at least part of these infections and this explains why strict compliance to the immunization guidelines specifically prepared for IBD patients is strongly recommended. However, several factors might lead to insufficient immunization. In this paper, present knowledge on the use of vaccines in children with IBDs is discussed. Literature review showed that despite a lack of detailed quantification of the risk of infections in children with IBDs, these children might have infections more frequently than age-matched healthy subjects, and at least in some cases, these infections might be even more severe. Fortunately, most of these infections could be prevented when recommended schedules of immunization are carefully followed. Vaccines given to children with IBDs generally have adequate immunogenicity and safety. Attention must be paid to live attenuated vaccines that can be administered only to children without or with mild immune system function impairment. Vaccination of their caregivers is also recommended. Unfortunately, compliance to these recommendations is generally low and multidisciplinary educational programs to improve vaccination coverage must be planned, in order to protect children with IBD from vaccine-preventable diseases.https://www.mdpi.com/2076-393X/9/5/487Crohn’s diseaseinflammatory bowel diseasesulcerative colitisvaccinationvaccine |
| spellingShingle | Susanna Esposito Giulia Antoniol Marialuisa Labate Lucrezia Passadore Patrizia Alvisi Valeria Daccò Chiara Ghizzi Carla Colombo Nicola Principi Vaccines in Children with Inflammatory Bowel Disease: Brief Review Vaccines Crohn’s disease inflammatory bowel diseases ulcerative colitis vaccination vaccine |
| title | Vaccines in Children with Inflammatory Bowel Disease: Brief Review |
| title_full | Vaccines in Children with Inflammatory Bowel Disease: Brief Review |
| title_fullStr | Vaccines in Children with Inflammatory Bowel Disease: Brief Review |
| title_full_unstemmed | Vaccines in Children with Inflammatory Bowel Disease: Brief Review |
| title_short | Vaccines in Children with Inflammatory Bowel Disease: Brief Review |
| title_sort | vaccines in children with inflammatory bowel disease brief review |
| topic | Crohn’s disease inflammatory bowel diseases ulcerative colitis vaccination vaccine |
| url | https://www.mdpi.com/2076-393X/9/5/487 |
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