Variation of total antioxidant status after ischemic stroke
There is strong evidence that oxidative stress appears to be a major contributor to ischemic brain injury. Objective: To study dynamic evolution of Total Antioxidant Status (TAS) and other markers of oxidative stress after ischemic stroke and to fi nd if there is any special correlation between the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2011-12-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2011.4/RJN_2011_4_Art-04.pdf |
| Summary: | There is strong evidence that oxidative stress appears to be a major contributor to ischemic brain injury.
Objective: To study dynamic evolution of Total Antioxidant Status (TAS) and other markers of oxidative stress after ischemic stroke and to fi nd if there is any special correlation between them or with clinical status.
Methods: in a prospective study we measured markers of oxidative stress – TAS, uric acid, albumin, LDL-cholesterol and CRP – as inflammatory marker, in 24 patients, initial and 2 months after the onset of stroke, and try to fi nd the evolution in time of these markers and if there is any correlation between them or with the neurologic deficit evaluated by NIHSS scale.
Results and conclusions: Levels of TAS and albumin were initial significant lower than in controls and 2 months after the stroke, higher than initial but still lower than in controls. We found a correlation between TAS and uric acid stronger and for CRP weaker at the onset than 2 months after the stroke. There was no correlation between NIHSS and TAS at both determinations. |
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| ISSN: | 1843-8148 2069-6094 |