Multiplex PCR-based next generation sequencing as a novel, targeted and accurate molecular approach for periprosthetic joint infection diagnosis

Multiplex PCR-based next generation sequencing as a novel, targeted and accurate molecular approach for periprosthetic joint infection diagnosis

ObjectivesPeriprosthetic joint infection (PJI) diagnosis remains challenging, and the identification of the causative microorganism is, by far, the most important aspect. Here, we use multiple PCR-based targeted next-generation sequencing (tNGS) to detect pathogens in PJI. To explore 1. the ability...

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Bibliographic Details
Main Authors: Changyu Huang, Ying Huang, Ziwen Wang, Yiming Lin, Yongbin Li, Yang Chen, Xiaoqing Chen, Chaofan Zhang, Wenbo Li, Wenming Zhang, Xinyu Fang, Zida Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Microbiology
Subjects:
periprosthetic joint infection
targeted next-generation sequencing
metagenomic next-generation sequencing
culture
diagnostics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1181348/full

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