Transiently antigen primed B cells can generate multiple subsets of memory cells.
Memory B cells are long-lived cells that generate a more vigorous response upon recognition of antigen (Ag) and T cell help than naïve B cells and ensure maintenance of durable humoral immunity. Functionally distinct subsets of murine memory B cells have been identified based on isotype switching of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5574538?pdf=render |
| _version_ | 1818957428213940224 |
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| author | Jackson S Turner Zachary L Benet Irina Grigorova |
| author_facet | Jackson S Turner Zachary L Benet Irina Grigorova |
| author_sort | Jackson S Turner |
| collection | DOAJ |
| description | Memory B cells are long-lived cells that generate a more vigorous response upon recognition of antigen (Ag) and T cell help than naïve B cells and ensure maintenance of durable humoral immunity. Functionally distinct subsets of murine memory B cells have been identified based on isotype switching of BCRs and surface expression of the co-stimulatory molecule CD80 and co-inhibitory molecule PD-L2. Memory B cells in a subpopulation with low surface expression of CD80 and PD-L2 are predominantly non-isotype switched and can be efficiently recruited into germinal centers (GCs) in secondary responses. In contrast, a CD80 and PD-L2 positive subset arises predominantly from GCs and can quickly differentiate into antibody-secreting plasma cells (PCs). Here we demonstrate that single transient acquisition of Ag by B cells may be sufficient for their long-term participation in GC responses and for development of various memory B cell subsets including CD80 and PD-L2 positive effector-like memory cells that rapidly differentiate into class-switched PCs during recall responses. |
| first_indexed | 2024-12-20T11:09:41Z |
| format | Article |
| id | doaj.art-6bb5d99b2a1c4496aabd07d2a9d7377d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T11:09:41Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6bb5d99b2a1c4496aabd07d2a9d7377d2022-12-21T19:42:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018387710.1371/journal.pone.0183877Transiently antigen primed B cells can generate multiple subsets of memory cells.Jackson S TurnerZachary L BenetIrina GrigorovaMemory B cells are long-lived cells that generate a more vigorous response upon recognition of antigen (Ag) and T cell help than naïve B cells and ensure maintenance of durable humoral immunity. Functionally distinct subsets of murine memory B cells have been identified based on isotype switching of BCRs and surface expression of the co-stimulatory molecule CD80 and co-inhibitory molecule PD-L2. Memory B cells in a subpopulation with low surface expression of CD80 and PD-L2 are predominantly non-isotype switched and can be efficiently recruited into germinal centers (GCs) in secondary responses. In contrast, a CD80 and PD-L2 positive subset arises predominantly from GCs and can quickly differentiate into antibody-secreting plasma cells (PCs). Here we demonstrate that single transient acquisition of Ag by B cells may be sufficient for their long-term participation in GC responses and for development of various memory B cell subsets including CD80 and PD-L2 positive effector-like memory cells that rapidly differentiate into class-switched PCs during recall responses.http://europepmc.org/articles/PMC5574538?pdf=render |
| spellingShingle | Jackson S Turner Zachary L Benet Irina Grigorova Transiently antigen primed B cells can generate multiple subsets of memory cells. PLoS ONE |
| title | Transiently antigen primed B cells can generate multiple subsets of memory cells. |
| title_full | Transiently antigen primed B cells can generate multiple subsets of memory cells. |
| title_fullStr | Transiently antigen primed B cells can generate multiple subsets of memory cells. |
| title_full_unstemmed | Transiently antigen primed B cells can generate multiple subsets of memory cells. |
| title_short | Transiently antigen primed B cells can generate multiple subsets of memory cells. |
| title_sort | transiently antigen primed b cells can generate multiple subsets of memory cells |
| url | http://europepmc.org/articles/PMC5574538?pdf=render |
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