IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport

IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport

The treatment of neurological disorders with large-molecule biotherapeutics requires that the therapeutic drug be transported across the blood–brain barrier (BBB). However, recombinant biotherapeutics, such as neurotrophins, enzymes, decoy receptors, and monoclonal antibodies (MAb), do not cross the...

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Bibliographic Details
Main Author:	Ruben J. Boado
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Series:	Pharmaceutics
Subjects:	blood–brain barrier protein-based therapy monoclonal antibody insulin receptor transferrin receptor lysosomal storage disorders
Online Access:	https://www.mdpi.com/1999-4923/14/7/1476

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