Accumbal Adenosine A2A Receptors Enhance Cognitive Flexibility by Facilitating Strategy Shifting

Accumbal Adenosine A2A Receptors Enhance Cognitive Flexibility by Facilitating Strategy Shifting

The deficits of cognitive flexibility (including attentional set-shifting and reversal learning) concomitant with dysfunction of the striatum are observed in several neuropsychiatric disorders. Rodent and human studies have identified the striatum [particularly the dorsomedial striatum (DMS) and nuc...

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Bibliographic Details
Main Authors: Jianhong Zhou, Beibei Wu, Xiangxiang Lin, Yuwei Dai, Tingting Li, Wu Zheng, Wei Guo, Sergii Vakal, Xingjun Chen, Jiang-Fan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
adenosine A2A receptors
nucleus accumbens
dorsomedial striatum
attentional set-shifting
reversal learning
motivation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00130/full

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