Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile
BackgroundSeveral 9p21.3 variants, such as rs1333049, rs4977574, rs10757274, rs10757278, and rs10811661, identified from recent genome-wide association studies (GWASs) are reported to be associated with coronary artery disease (CAD) susceptibility but independent of dyslipidemia. This study investig...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.946289/full |
| _version_ | 1818482263328817152 |
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| author | Baozhu Wei Baozhu Wei Yang Liu Hang Li Yuanyuan Peng Zhi Luo |
| author_facet | Baozhu Wei Baozhu Wei Yang Liu Hang Li Yuanyuan Peng Zhi Luo |
| author_sort | Baozhu Wei |
| collection | DOAJ |
| description | BackgroundSeveral 9p21.3 variants, such as rs1333049, rs4977574, rs10757274, rs10757278, and rs10811661, identified from recent genome-wide association studies (GWASs) are reported to be associated with coronary artery disease (CAD) susceptibility but independent of dyslipidemia. This study investigated whether these 9p21.3 variants influenced lipid profiles.Methods and resultsBy searching the PubMed and Cochrane databases, 101,099 individuals were included in the analysis. The consistent finding for the rs1333049 C allele on lipid profiles increased the triglyceride (TG) levels. Moreover, the rs4977574 G allele and the rs10757274 G allele, respectively, increased low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels. However, the rs10811661 C allele largely reduced LDL-C levels. Subgroup analyses indicated that the effects of the rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele on lipid profiles were stronger in Whites compared with Asians. In contrast, the effect of the rs10811661 C allele on lipid profiles was stronger in Asians compared with Whites.ConclusionThe rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele of lncRNA, and the rs10811661 G allele of CDKN2A/2B had a significant influence on lipid levels, which may help the understanding of the underlying mechanisms between 9p21.3 variants and CAD. |
| first_indexed | 2024-12-10T11:45:25Z |
| format | Article |
| id | doaj.art-6bb7d55d3a0742fb99982c1e2696bd04 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-10T11:45:25Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-6bb7d55d3a0742fb99982c1e2696bd042022-12-22T01:50:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.946289946289Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profileBaozhu Wei0Baozhu Wei1Yang Liu2Hang Li3Yuanyuan Peng4Zhi Luo5Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaInstitute of Myocardial Injury and Repair, Wuhan University, Wuhan, ChinaDepartment of Endocrinology, China Resources and WISCO General Hospital, Wuhan, ChinaDepartment of Gerontology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, ChinaBackgroundSeveral 9p21.3 variants, such as rs1333049, rs4977574, rs10757274, rs10757278, and rs10811661, identified from recent genome-wide association studies (GWASs) are reported to be associated with coronary artery disease (CAD) susceptibility but independent of dyslipidemia. This study investigated whether these 9p21.3 variants influenced lipid profiles.Methods and resultsBy searching the PubMed and Cochrane databases, 101,099 individuals were included in the analysis. The consistent finding for the rs1333049 C allele on lipid profiles increased the triglyceride (TG) levels. Moreover, the rs4977574 G allele and the rs10757274 G allele, respectively, increased low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels. However, the rs10811661 C allele largely reduced LDL-C levels. Subgroup analyses indicated that the effects of the rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele on lipid profiles were stronger in Whites compared with Asians. In contrast, the effect of the rs10811661 C allele on lipid profiles was stronger in Asians compared with Whites.ConclusionThe rs1333049 C allele, rs4977574 G allele, and rs10757274 G allele of lncRNA, and the rs10811661 G allele of CDKN2A/2B had a significant influence on lipid levels, which may help the understanding of the underlying mechanisms between 9p21.3 variants and CAD.https://www.frontiersin.org/articles/10.3389/fcvm.2022.946289/fulllncRNACDKN2A/2Bvariantdyslipidemiacoronary artery disease |
| spellingShingle | Baozhu Wei Baozhu Wei Yang Liu Hang Li Yuanyuan Peng Zhi Luo Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile Frontiers in Cardiovascular Medicine lncRNA CDKN2A/2B variant dyslipidemia coronary artery disease |
| title | Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile |
| title_full | Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile |
| title_fullStr | Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile |
| title_full_unstemmed | Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile |
| title_short | Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile |
| title_sort | effect of 9p21 3 lncrna and cdkn2a 2b variant on lipid profile |
| topic | lncRNA CDKN2A/2B variant dyslipidemia coronary artery disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.946289/full |
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