Serum Myostatin among Excessive Drinkers
Myostatin acts as a negative regulator of muscle growth. Its effect on fat mass is subject to debate. Among alcoholics, there is a high prevalence of muscle atrophy, and increased fat deposition has been also described in these patients. Myostatin could be involved in these alterations, but its rela...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2981 |
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| author | Candelaria Martín-González Onán Pérez-Hernández Alen García-Rodríguez Pedro Abreu-González Paula Ortega-Toledo Camino María Fernández-Rodríguez Julio César Alvisa-Negrín Antonio Martínez-Riera Emilio González-Reimers |
| author_facet | Candelaria Martín-González Onán Pérez-Hernández Alen García-Rodríguez Pedro Abreu-González Paula Ortega-Toledo Camino María Fernández-Rodríguez Julio César Alvisa-Negrín Antonio Martínez-Riera Emilio González-Reimers |
| author_sort | Candelaria Martín-González |
| collection | DOAJ |
| description | Myostatin acts as a negative regulator of muscle growth. Its effect on fat mass is subject to debate. Among alcoholics, there is a high prevalence of muscle atrophy, and increased fat deposition has been also described in these patients. Myostatin could be involved in these alterations, but its relationships with body composition have been scarcely studied in alcoholic patients. To analyze the behavior of myostatin among alcoholics and its relationship with alcohol intake, liver function, and body composition. We investigated serum myostatin in 59 male patients and 18 controls. Patients were all heavy drinkers admitted with organic complications related to excessive ethanol ingestion. Densitometry analysis was used to assess body composition in 46 patients. Handgrip was assessed in 51 patients. Patients showed lower myostatin values than controls (Z = 3.80; <i>p</i> < 0.001). There was a significant relationship between myostatin and fat at the right leg (ρ = 0.32; <i>p</i> = 0.028), left leg (ρ = 0.32; <i>p</i> = 0.028), trunk (ρ = 0.31, <i>p</i> = 0.038), total fat proport ion (ρ = 0.33, <i>p</i> = 0.026), and gynecoid fat distribution (ρ = 0.40, <i>p</i> = 0.006) but not with lean mass (total lean ρ = 0.07; <i>p</i> = 0.63; trunk lean ρ = 0.03; <i>p</i> = 0.85; lower limbs ρ = 0.08; <i>p</i> = 0.58; upper limbs ρ = 0.04 <i>p</i> = 0.82; android ρ = 0.02; <i>p</i> = 0.88, or gynoid lean mass ρ = 0.20; <i>p</i> = 0.19). In total, 80.43% of patients showed at least one criterion of osteosarcopenic adiposity (OSA). Myostatin was related to OSA obesity. We also observed higher myostatin values among patients with body mass index > 30 kg/m<sup>2</sup>. Serum myostatin was lower among excessive drinkers, and it was related to increased fat deposition among these patients but not to lean mass, handgrip, or bone mineral density. |
| first_indexed | 2024-03-11T09:38:58Z |
| format | Article |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:38:58Z |
| publishDate | 2023-02-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6bb7e455799f425fbb012d5c26a84a852023-11-16T17:05:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01243298110.3390/ijms24032981Serum Myostatin among Excessive DrinkersCandelaria Martín-González0Onán Pérez-Hernández1Alen García-Rodríguez2Pedro Abreu-González3Paula Ortega-Toledo4Camino María Fernández-Rodríguez5Julio César Alvisa-Negrín6Antonio Martínez-Riera7Emilio González-Reimers8Departamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Ciencias Médicas Básicas, Unidad de Fisiología, Universidad de la Laguna, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainDepartamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, SpainMyostatin acts as a negative regulator of muscle growth. Its effect on fat mass is subject to debate. Among alcoholics, there is a high prevalence of muscle atrophy, and increased fat deposition has been also described in these patients. Myostatin could be involved in these alterations, but its relationships with body composition have been scarcely studied in alcoholic patients. To analyze the behavior of myostatin among alcoholics and its relationship with alcohol intake, liver function, and body composition. We investigated serum myostatin in 59 male patients and 18 controls. Patients were all heavy drinkers admitted with organic complications related to excessive ethanol ingestion. Densitometry analysis was used to assess body composition in 46 patients. Handgrip was assessed in 51 patients. Patients showed lower myostatin values than controls (Z = 3.80; <i>p</i> < 0.001). There was a significant relationship between myostatin and fat at the right leg (ρ = 0.32; <i>p</i> = 0.028), left leg (ρ = 0.32; <i>p</i> = 0.028), trunk (ρ = 0.31, <i>p</i> = 0.038), total fat proport ion (ρ = 0.33, <i>p</i> = 0.026), and gynecoid fat distribution (ρ = 0.40, <i>p</i> = 0.006) but not with lean mass (total lean ρ = 0.07; <i>p</i> = 0.63; trunk lean ρ = 0.03; <i>p</i> = 0.85; lower limbs ρ = 0.08; <i>p</i> = 0.58; upper limbs ρ = 0.04 <i>p</i> = 0.82; android ρ = 0.02; <i>p</i> = 0.88, or gynoid lean mass ρ = 0.20; <i>p</i> = 0.19). In total, 80.43% of patients showed at least one criterion of osteosarcopenic adiposity (OSA). Myostatin was related to OSA obesity. We also observed higher myostatin values among patients with body mass index > 30 kg/m<sup>2</sup>. Serum myostatin was lower among excessive drinkers, and it was related to increased fat deposition among these patients but not to lean mass, handgrip, or bone mineral density.https://www.mdpi.com/1422-0067/24/3/2981alcoholismmyostatinfat masssarcopenic obesity |
| spellingShingle | Candelaria Martín-González Onán Pérez-Hernández Alen García-Rodríguez Pedro Abreu-González Paula Ortega-Toledo Camino María Fernández-Rodríguez Julio César Alvisa-Negrín Antonio Martínez-Riera Emilio González-Reimers Serum Myostatin among Excessive Drinkers International Journal of Molecular Sciences alcoholism myostatin fat mass sarcopenic obesity |
| title | Serum Myostatin among Excessive Drinkers |
| title_full | Serum Myostatin among Excessive Drinkers |
| title_fullStr | Serum Myostatin among Excessive Drinkers |
| title_full_unstemmed | Serum Myostatin among Excessive Drinkers |
| title_short | Serum Myostatin among Excessive Drinkers |
| title_sort | serum myostatin among excessive drinkers |
| topic | alcoholism myostatin fat mass sarcopenic obesity |
| url | https://www.mdpi.com/1422-0067/24/3/2981 |
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