Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems
In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active subs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/14/4142 |
| _version_ | 1797526536584167424 |
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| author | Marianna Porcino Xue Li Ruxandra Gref Charlotte Martineau-Corcos |
| author_facet | Marianna Porcino Xue Li Ruxandra Gref Charlotte Martineau-Corcos |
| author_sort | Marianna Porcino |
| collection | DOAJ |
| description | In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design. |
| first_indexed | 2024-03-10T09:31:30Z |
| format | Article |
| id | doaj.art-6bbe6018c4fd41aa998b3f586cac605b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:31:30Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6bbe6018c4fd41aa998b3f586cac605b2023-11-22T04:29:12ZengMDPI AGMolecules1420-30492021-07-012614414210.3390/molecules26144142Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery SystemsMarianna Porcino0Xue Li1Ruxandra Gref2Charlotte Martineau-Corcos3CEMHTI UPR CNRS 3079, Université d’Orléans, 45071 Orléans, FranceInstitut des Sciences Moléculaires d’Orsay, UMR CNRS 8214, Paris-Sud University, Université Paris Saclay, 91400 Orsay, FranceInstitut des Sciences Moléculaires d’Orsay, UMR CNRS 8214, Paris-Sud University, Université Paris Saclay, 91400 Orsay, FranceCortecNet, 7 Avenue du Hoggar, 91940 Les Ulis, FranceIn the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design.https://www.mdpi.com/1420-3049/26/14/4142solid-state NMR spectroscopyporous materialdrug delivery systemheteronuclei |
| spellingShingle | Marianna Porcino Xue Li Ruxandra Gref Charlotte Martineau-Corcos Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems Molecules solid-state NMR spectroscopy porous material drug delivery system heteronuclei |
| title | Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems |
| title_full | Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems |
| title_fullStr | Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems |
| title_full_unstemmed | Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems |
| title_short | Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems |
| title_sort | solid state nmr spectroscopy a key tool to unravel the supramolecular structure of drug delivery systems |
| topic | solid-state NMR spectroscopy porous material drug delivery system heteronuclei |
| url | https://www.mdpi.com/1420-3049/26/14/4142 |
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