Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis
Objective: Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that inreased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2014-02-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-52959 |
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| author | Gurkan Acar Murat Akkoyun Alper Buğra Nacar İmran Dirnak Gözde Yıldırım Çetin Makbule Nur Yıldırım Cemil Zencir Kayıhan Karaman Mustafa Çetin Mehmet Sayarlıoğlu |
| author_facet | Gurkan Acar Murat Akkoyun Alper Buğra Nacar İmran Dirnak Gözde Yıldırım Çetin Makbule Nur Yıldırım Cemil Zencir Kayıhan Karaman Mustafa Çetin Mehmet Sayarlıoğlu |
| author_sort | Gurkan Acar |
| collection | DOAJ |
| description | Objective: Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that inreased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate ventricular repolarization by using Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis (RA), and to assess the relation with inflammation.
Study design: Ninety-six patients with RA and and 50 controls were included. From the 12-lead electrocardiogram Tp-e interval and Tp-e/QT ratio were measured. Blood samples were taken for erythrocyte sedimentation rate (ESR) and plasma levels of C-reactive protein (CRP). These parameters were compared between groups. The relationship between ventricular repolarization and inflammation was assessed by Pearson correlation coefficients.
Results: Tp-e interval and Tp-e/QT ratio were increased in RA patients compared to the controls (72.6+-8.2 vs 66.4+-8.5 milliseconds, 0.20 +- 0.02 vs 0.18 +- 0.02; P<0.001 and P<0.001, respectively). Tp-e interval was significantly correlated with CRP, ESR, and disease acticity score (DAS-28) (r=0.56, P<0.001, r=0.57, P<0.001, and r=0.29, P=0.02, respectively). Tp-e/QT ratio was also correlated with CRP, ESR, and DAS-28 score (r=0.43, P<0.001, r=0.53, P<0.001, and r=0.25, P=0.03, respectively).
Conclusions: Increased frequency of ventricular arrhythmias may explain by increased indexes of ventricular repolarization and their relationship with inflammation in RA patients. |
| first_indexed | 2024-04-10T14:06:30Z |
| format | Article |
| id | doaj.art-6bc16df849cd429fa415841d571d2b38 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T14:06:30Z |
| publishDate | 2014-02-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-6bc16df849cd429fa415841d571d2b382023-02-15T16:09:56ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692014-02-01421293410.5543/tkda.2014/52959TKDA-52959Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritisGurkan Acar0Murat Akkoyun1Alper Buğra Nacar2İmran Dirnak3Gözde Yıldırım Çetin4Makbule Nur Yıldırım5Cemil Zencir6Kayıhan Karaman7Mustafa Çetin8Mehmet Sayarlıoğlu9Department of Cardiology, Kahramanmaraş Necip Fazil State Hospital, KahramanmaraşDepartment of Cardiology, Kahramanmaraş Necip Fazil State Hospital, KahramanmaraşDepartment of Cardiology, Kahramanmaraş Necip Fazil State Hospital, KahramanmaraşDepartment of Cardiology, Kahramanmaraş Necip Fazil State Hospital, KahramanmaraşDepartment of Cardiology, Kahramanmaras Sutcu Imam University Faculty of Medicine, KahramanmarasDepartment of Rheumatology, Kahramanmaras Sutcu Imam University Faculty of Medicine, KahramanmarasDepartment of Rheumatology, Kahramanmaras Sutcu Imam University Faculty of Medicine, KahramanmarasDepartment of Rheumatology, Kahramanmaras Sutcu Imam University Faculty of Medicine, KahramanmarasDepartment of Rheumatology, Kahramanmaras Sutcu Imam University Faculty of Medicine, KahramanmarasDepartment of Cardiology, Kahramanmaras Sutcu Imam University Faculty of Medicine, KahramanmarasObjective: Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that inreased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate ventricular repolarization by using Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis (RA), and to assess the relation with inflammation. Study design: Ninety-six patients with RA and and 50 controls were included. From the 12-lead electrocardiogram Tp-e interval and Tp-e/QT ratio were measured. Blood samples were taken for erythrocyte sedimentation rate (ESR) and plasma levels of C-reactive protein (CRP). These parameters were compared between groups. The relationship between ventricular repolarization and inflammation was assessed by Pearson correlation coefficients. Results: Tp-e interval and Tp-e/QT ratio were increased in RA patients compared to the controls (72.6+-8.2 vs 66.4+-8.5 milliseconds, 0.20 +- 0.02 vs 0.18 +- 0.02; P<0.001 and P<0.001, respectively). Tp-e interval was significantly correlated with CRP, ESR, and disease acticity score (DAS-28) (r=0.56, P<0.001, r=0.57, P<0.001, and r=0.29, P=0.02, respectively). Tp-e/QT ratio was also correlated with CRP, ESR, and DAS-28 score (r=0.43, P<0.001, r=0.53, P<0.001, and r=0.25, P=0.03, respectively). Conclusions: Increased frequency of ventricular arrhythmias may explain by increased indexes of ventricular repolarization and their relationship with inflammation in RA patients.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-52959electrocardiograminflammationventricular arrhythmogenesisventricular repolarization |
| spellingShingle | Gurkan Acar Murat Akkoyun Alper Buğra Nacar İmran Dirnak Gözde Yıldırım Çetin Makbule Nur Yıldırım Cemil Zencir Kayıhan Karaman Mustafa Çetin Mehmet Sayarlıoğlu Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis Türk Kardiyoloji Derneği Arşivi electrocardiogram inflammation ventricular arrhythmogenesis ventricular repolarization |
| title | Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis |
| title_full | Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis |
| title_fullStr | Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis |
| title_full_unstemmed | Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis |
| title_short | Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis |
| title_sort | evaluation of tp e interval and tp e qt ratio in patients with rheumatoid arthritis |
| topic | electrocardiogram inflammation ventricular arrhythmogenesis ventricular repolarization |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-52959 |
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