Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice
Abstract Introduction Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.438 |
| _version_ | 1827820644344004608 |
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| author | Bahar Atabaki Naser Mirazi Abdolkarim Hosseini Abdolrahman Sarihi Zahra Izadi Alireza Nourian |
| author_facet | Bahar Atabaki Naser Mirazi Abdolkarim Hosseini Abdolrahman Sarihi Zahra Izadi Alireza Nourian |
| author_sort | Bahar Atabaki |
| collection | DOAJ |
| description | Abstract Introduction Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study. Methods In this study 42 male mice, weighing (25–35 g) were randomly divided in six groups: control group (taking normal saline, 0.5 mL/day, by oral gavage [P.O.]), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2 weeks), hypothyroid groups treated by levothyroxine (15 mg/kg/day, P.O.) and hypothyroid groups treated by ECE (100, 200 and 400 mg/kg/day, P.O.). After the end of experiments the mice were anaesthetised and blood samples were collected for hormonal analysis. Results The sperm count and microscopic studies of testes were done also. Our results showed that the T3, T4, testosterone levels and spermatogenesis in hypothyroid animals decreased and thyroid‐stimulating hormone, follicle‐stimulating hormone and luteinizing hormone increased compared with control group. Treatment by ECE reverse these effects in comparison with hypothyroid group. Conclusions According to our findings, the ECE may stimulates thyroid gland function and increases testosterone and spermatogenesis. |
| first_indexed | 2024-03-12T01:31:15Z |
| format | Article |
| id | doaj.art-6bc2e5c0f2184bdeab5753371ab394e2 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-03-12T01:31:15Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-6bc2e5c0f2184bdeab5753371ab394e22023-09-12T04:11:09ZengWileyEndocrinology, Diabetes & Metabolism2398-92382023-09-0165n/an/a10.1002/edm2.438Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c miceBahar Atabaki0Naser Mirazi1Abdolkarim Hosseini2Abdolrahman Sarihi3Zahra Izadi4Alireza Nourian5Department of Biology, Faculty of Basic Sciences Islamic Azad University Hamedan IranDepartment of Biology, Faculty of Basic Sciences Bu‐Ali Sina University Hamedan IranDepartment of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology Shahid Beheshti University Tehran IranDepartment of Neuroscience, School of Sciences and Advanced Technology in Medicine Hamadan University of Medical Sciences Hamadan IranDepartment of Horticulture Sciences and Engineering, Nahavand Higher Education Complex Bu‐Ali Sina University Hamedan IranDepartment of Pathobiology, Faculty of Veterinary Science Bu‐Ali Sina University Hamedan IranAbstract Introduction Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study. Methods In this study 42 male mice, weighing (25–35 g) were randomly divided in six groups: control group (taking normal saline, 0.5 mL/day, by oral gavage [P.O.]), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2 weeks), hypothyroid groups treated by levothyroxine (15 mg/kg/day, P.O.) and hypothyroid groups treated by ECE (100, 200 and 400 mg/kg/day, P.O.). After the end of experiments the mice were anaesthetised and blood samples were collected for hormonal analysis. Results The sperm count and microscopic studies of testes were done also. Our results showed that the T3, T4, testosterone levels and spermatogenesis in hypothyroid animals decreased and thyroid‐stimulating hormone, follicle‐stimulating hormone and luteinizing hormone increased compared with control group. Treatment by ECE reverse these effects in comparison with hypothyroid group. Conclusions According to our findings, the ECE may stimulates thyroid gland function and increases testosterone and spermatogenesis.https://doi.org/10.1002/edm2.438Elettaria cardamomumhypothyroidismspermatogenesis |
| spellingShingle | Bahar Atabaki Naser Mirazi Abdolkarim Hosseini Abdolrahman Sarihi Zahra Izadi Alireza Nourian Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice Endocrinology, Diabetes & Metabolism Elettaria cardamomum hypothyroidism spermatogenesis |
| title | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice |
| title_full | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice |
| title_fullStr | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice |
| title_full_unstemmed | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice |
| title_short | Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil‐induced hypothyroidism male BALB/c mice |
| title_sort | effect of elettaria cardamomum l on hormonal changes and spermatogenesis in the propylthiouracil induced hypothyroidism male balb c mice |
| topic | Elettaria cardamomum hypothyroidism spermatogenesis |
| url | https://doi.org/10.1002/edm2.438 |
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