The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.
Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions are urgently required. Cathelicidins are cationic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3758310?pdf=render |
| _version_ | 1818691823683502080 |
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| author | Silke M Currie Emily Gwyer Findlay Brian J McHugh Annie Mackellar Tian Man Derek Macmillan Hongwei Wang Paul M Fitch Jürgen Schwarze Donald J Davidson |
| author_facet | Silke M Currie Emily Gwyer Findlay Brian J McHugh Annie Mackellar Tian Man Derek Macmillan Hongwei Wang Paul M Fitch Jürgen Schwarze Donald J Davidson |
| author_sort | Silke M Currie |
| collection | DOAJ |
| description | Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions are urgently required. Cathelicidins are cationic host defence peptides expressed in the inflamed lung, with key roles in innate host defence against infection. We demonstrate that the human cathelicidin LL-37 has effective antiviral activity against RSV in vitro, retained by a truncated central peptide fragment. LL-37 prevented virus-induced cell death in epithelial cultures, significantly inhibited the production of new infectious particles and diminished the spread of infection, with antiviral effects directed both against the viral particles and the epithelial cells. LL-37 may represent an important targetable component of innate host defence against RSV infection. Prophylactic modulation of LL-37 expression and/or use of synthetic analogues post-infection may represent future novel strategies against RSV infection. |
| first_indexed | 2024-12-17T12:48:01Z |
| format | Article |
| id | doaj.art-6bc4431fc09a4e508c8c07a5dfaab2b8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T12:48:01Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6bc4431fc09a4e508c8c07a5dfaab2b82022-12-21T21:47:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7365910.1371/journal.pone.0073659The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.Silke M CurrieEmily Gwyer FindlayBrian J McHughAnnie MackellarTian ManDerek MacmillanHongwei WangPaul M FitchJürgen SchwarzeDonald J DavidsonRespiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently, there is no effective vaccine or disease modifying treatment available and novel interventions are urgently required. Cathelicidins are cationic host defence peptides expressed in the inflamed lung, with key roles in innate host defence against infection. We demonstrate that the human cathelicidin LL-37 has effective antiviral activity against RSV in vitro, retained by a truncated central peptide fragment. LL-37 prevented virus-induced cell death in epithelial cultures, significantly inhibited the production of new infectious particles and diminished the spread of infection, with antiviral effects directed both against the viral particles and the epithelial cells. LL-37 may represent an important targetable component of innate host defence against RSV infection. Prophylactic modulation of LL-37 expression and/or use of synthetic analogues post-infection may represent future novel strategies against RSV infection.http://europepmc.org/articles/PMC3758310?pdf=render |
| spellingShingle | Silke M Currie Emily Gwyer Findlay Brian J McHugh Annie Mackellar Tian Man Derek Macmillan Hongwei Wang Paul M Fitch Jürgen Schwarze Donald J Davidson The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. PLoS ONE |
| title | The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. |
| title_full | The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. |
| title_fullStr | The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. |
| title_full_unstemmed | The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. |
| title_short | The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. |
| title_sort | human cathelicidin ll 37 has antiviral activity against respiratory syncytial virus |
| url | http://europepmc.org/articles/PMC3758310?pdf=render |
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