Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants
New oral anticoagulant agents continue to emerge on the market and their safety requires assessment to provide evidence of their suitability for clinical use. There-fore, we searched standard databases to summarize the English language literature on medicine-related problems (MRPs) of direct oral an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2017-10-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/33/ |
| _version_ | 1797821700786618368 |
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| author | Huda Alewairdhi Nkiruka Umaru Zoe Aslanpour |
| author_facet | Huda Alewairdhi Nkiruka Umaru Zoe Aslanpour |
| author_sort | Huda Alewairdhi |
| collection | DOAJ |
| description | New oral anticoagulant agents continue to emerge on the market and their safety requires assessment to provide evidence of their suitability for clinical use. There-fore, we searched standard databases to summarize the English language literature on medicine-related problems (MRPs) of direct oral anticoagulants DOACs (dabigtran, rivaroxban, apixban, and edoxban) in the treatment of adults with atri-al fibrillation. Electronic databases including Medline, Embase, International Pharmaceutical Abstract (IPA), Scopus, CINAHL, the Web of Science and Cochrane were searched from 2008 through 2016 for original articles. Studies pub-lished in English reporting MRPs of DOACs in adult patients with AF were in-cluded. Seventeen studies were identified using standardized protocols, and two reviewers serially abstracted data from each article. Most articles were inconclusive on major safety end points including major bleeding. Data on major safety end points were combined with efficacy. Most studies inconsistently reported adverse drug reactions and not adverse events or medication error, and no definitions were consistent across studies. Some harmful drug effects were not assessed in studies and may have been overlooked. Little evidence is provided on MRPs of DOACs in patients with AF and, therefore, further studies are needed to establish the safety of DOACs in real-life clinical practice. |
| first_indexed | 2024-03-13T09:57:40Z |
| format | Article |
| id | doaj.art-6bc5838189c746b7b118445620fc1a5e |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T09:57:40Z |
| publishDate | 2017-10-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-6bc5838189c746b7b118445620fc1a5e2023-05-23T14:55:40ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562017-10-012210.5920/bjpharm.2017.07Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral AnticoagulantsHuda Alewairdhi Nkiruka UmaruZoe AslanpourNew oral anticoagulant agents continue to emerge on the market and their safety requires assessment to provide evidence of their suitability for clinical use. There-fore, we searched standard databases to summarize the English language literature on medicine-related problems (MRPs) of direct oral anticoagulants DOACs (dabigtran, rivaroxban, apixban, and edoxban) in the treatment of adults with atri-al fibrillation. Electronic databases including Medline, Embase, International Pharmaceutical Abstract (IPA), Scopus, CINAHL, the Web of Science and Cochrane were searched from 2008 through 2016 for original articles. Studies pub-lished in English reporting MRPs of DOACs in adult patients with AF were in-cluded. Seventeen studies were identified using standardized protocols, and two reviewers serially abstracted data from each article. Most articles were inconclusive on major safety end points including major bleeding. Data on major safety end points were combined with efficacy. Most studies inconsistently reported adverse drug reactions and not adverse events or medication error, and no definitions were consistent across studies. Some harmful drug effects were not assessed in studies and may have been overlooked. Little evidence is provided on MRPs of DOACs in patients with AF and, therefore, further studies are needed to establish the safety of DOACs in real-life clinical practice.https://www.bjpharm.org.uk/article/id/33/clinical practiceadult patientsatrial fibrillationoral anticoagulantsmedicine |
| spellingShingle | Huda Alewairdhi Nkiruka Umaru Zoe Aslanpour Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants British Journal of Pharmacy clinical practice adult patients atrial fibrillation oral anticoagulants medicine |
| title | Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants |
| title_full | Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants |
| title_fullStr | Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants |
| title_full_unstemmed | Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants |
| title_short | Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants |
| title_sort | systematic review of medicine related problems in adult patients with atrial fibrillation on direct oral anticoagulants |
| topic | clinical practice adult patients atrial fibrillation oral anticoagulants medicine |
| url | https://www.bjpharm.org.uk/article/id/33/ |
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