Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration
Different types of biomaterials have been used to fabricate carriers to deliver bone morphogenetic proteins (BMPs) in both dentoalveolar and maxillofacial bone regeneration procedures. Despite that absorbable collagen sponge (ACS) is considered the gold standard for BMP delivery, there is still some...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761622000242 |
| _version_ | 1797977744517103616 |
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| author | Alain Arias-Betancur Nicolás Badilla-Wenzel Álvaro Astete-Sanhueza Nicole Farfán-Beltrán Fernando José Dias |
| author_facet | Alain Arias-Betancur Nicolás Badilla-Wenzel Álvaro Astete-Sanhueza Nicole Farfán-Beltrán Fernando José Dias |
| author_sort | Alain Arias-Betancur |
| collection | DOAJ |
| description | Different types of biomaterials have been used to fabricate carriers to deliver bone morphogenetic proteins (BMPs) in both dentoalveolar and maxillofacial bone regeneration procedures. Despite that absorbable collagen sponge (ACS) is considered the gold standard for BMP delivery, there is still some concerns regarding its use mainly due to its poor mechanical properties. To overcome this, novel systems are being developed, however, due to the wide variety of biomaterial combination, the heterogeneous assessment of newly formed tissue, and the intended clinical applications, there is still no consensus regarding which is more efficient in a particular clinical scenario. The combination of two or more biomaterials in different topological configurations has allowed specific controlled-release patterns for BMPs, improving their biological and mechanical properties compared with classical single-material carriers. However, more basic research is needed. Since the BMPs can be used in multiple clinical scenarios having different biological and mechanical needs, novel carriers should be developed in a context-specific manner. Thus, the purpose of this review is to gather current knowledge about biomaterials used to fabricate delivery systems for BMPs in both dentoalveolar and maxillofacial contexts. Aspects related with the biological, physical and mechanical characteristics of each biomaterial are also presented and discussed. |
| first_indexed | 2024-04-11T05:11:52Z |
| format | Article |
| id | doaj.art-6bc668f1b6a74fc5b80d1a1546ad1ea6 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-04-11T05:11:52Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-6bc668f1b6a74fc5b80d1a1546ad1ea62022-12-25T04:17:33ZengElsevierJapanese Dental Science Review1882-76162022-11-0158316327Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regenerationAlain Arias-Betancur0Nicolás Badilla-Wenzel1Álvaro Astete-Sanhueza2Nicole Farfán-Beltrán3Fernando José Dias4Department of Integral Adult Dentistry, Research Centre for Dental Sciences (CICO-UFRO), Dental School-Facultad de Odontología, Universidad de La Frontera, Temuco 4811230, ChileDental School-Facultad de Odontología, Universidad de La Frontera, Temuco 4811230, ChileDental School-Facultad de Odontología, Universidad de La Frontera, Temuco 4811230, ChileDepartment of Integral Adult Dentistry, Research Centre for Dental Sciences (CICO-UFRO), Dental School-Facultad de Odontología, Universidad de La Frontera, Temuco 4811230, Chile; Universidad Adventista de Chile, Chillán 3780000, ChileDepartment of Integral Adult Dentistry, Oral Biology Research Centre (CIBO-UFRO), Dental School-Facultad de Odontología, Universidad de La Frontera, Temuco 4811230, Chile; Correspondence to: Dental School-Facultad de Odontología, Universidad de La Frontera, Av. Francisco Salazar 01145, Temuco 4811230, Chile.Different types of biomaterials have been used to fabricate carriers to deliver bone morphogenetic proteins (BMPs) in both dentoalveolar and maxillofacial bone regeneration procedures. Despite that absorbable collagen sponge (ACS) is considered the gold standard for BMP delivery, there is still some concerns regarding its use mainly due to its poor mechanical properties. To overcome this, novel systems are being developed, however, due to the wide variety of biomaterial combination, the heterogeneous assessment of newly formed tissue, and the intended clinical applications, there is still no consensus regarding which is more efficient in a particular clinical scenario. The combination of two or more biomaterials in different topological configurations has allowed specific controlled-release patterns for BMPs, improving their biological and mechanical properties compared with classical single-material carriers. However, more basic research is needed. Since the BMPs can be used in multiple clinical scenarios having different biological and mechanical needs, novel carriers should be developed in a context-specific manner. Thus, the purpose of this review is to gather current knowledge about biomaterials used to fabricate delivery systems for BMPs in both dentoalveolar and maxillofacial contexts. Aspects related with the biological, physical and mechanical characteristics of each biomaterial are also presented and discussed.http://www.sciencedirect.com/science/article/pii/S1882761622000242Bone regenerationDentoalveolar bone regenerationMaxillofacial bone regenerationBone morphogenetic proteinGrowth factorsCarriers |
| spellingShingle | Alain Arias-Betancur Nicolás Badilla-Wenzel Álvaro Astete-Sanhueza Nicole Farfán-Beltrán Fernando José Dias Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration Japanese Dental Science Review Bone regeneration Dentoalveolar bone regeneration Maxillofacial bone regeneration Bone morphogenetic protein Growth factors Carriers |
| title | Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration |
| title_full | Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration |
| title_fullStr | Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration |
| title_full_unstemmed | Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration |
| title_short | Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration |
| title_sort | carrier systems for bone morphogenetic proteins an overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration |
| topic | Bone regeneration Dentoalveolar bone regeneration Maxillofacial bone regeneration Bone morphogenetic protein Growth factors Carriers |
| url | http://www.sciencedirect.com/science/article/pii/S1882761622000242 |
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