The 26S Proteasome Switches between ATP-Dependent and -Independent Mechanisms in Response to Substrate Ubiquitination

The 26S Proteasome Switches between ATP-Dependent and -Independent Mechanisms in Response to Substrate Ubiquitination

The ubiquitin–proteasome system is responsible for the bulk of protein degradation in eukaryotic cells. Proteins are generally targeted to the 26S proteasome through the attachment of polyubiquitin chains. Several proteins also contain ubiquitin-independent degrons (UbIDs) that allow for proteasomal...

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Bibliographic Details
Main Authors: Abramo J. Manfredonia, Daniel A. Kraut
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomolecules
Subjects:
ubiquitin
ubiquitin–proteasome system
proteasome
ATP-dependent protease
protein degradation
Online Access:https://www.mdpi.com/2218-273X/12/6/750

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