Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
One potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1A2 and utrophin level in mice, leading to improvem...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15971-w |
| _version_ | 1818433587761905664 |
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| author | Christine Péladeau Nadine Adam Lucas M. Bronicki Adèle Coriati Mohamed Thabet Hasanen Al-Rewashdy Jason Vanstone Alan Mears Jean-Marc Renaud Martin Holcik Bernard J. Jasmin |
| author_facet | Christine Péladeau Nadine Adam Lucas M. Bronicki Adèle Coriati Mohamed Thabet Hasanen Al-Rewashdy Jason Vanstone Alan Mears Jean-Marc Renaud Martin Holcik Bernard J. Jasmin |
| author_sort | Christine Péladeau |
| collection | DOAJ |
| description | One potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1A2 and utrophin level in mice, leading to improvement of the dystrophic phenotype. |
| first_indexed | 2024-12-14T16:23:28Z |
| format | Article |
| id | doaj.art-6bc7a05ce66e4135bb35be45df6c5df1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:23:28Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6bc7a05ce66e4135bb35be45df6c5df12022-12-21T22:54:44ZengNature PortfolioNature Communications2041-17232020-04-0111111410.1038/s41467-020-15971-wIdentification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic musclesChristine Péladeau0Nadine Adam1Lucas M. Bronicki2Adèle Coriati3Mohamed Thabet4Hasanen Al-Rewashdy5Jason Vanstone6Alan Mears7Jean-Marc Renaud8Martin Holcik9Bernard J. Jasmin10Department of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaApoptosis Research Centre, Children’s Hospital of Eastern Ontario Research InstituteApoptosis Research Centre, Children’s Hospital of Eastern Ontario Research InstituteDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaDepartment of Health Sciences, Carleton UniversityDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of OttawaOne potential approach for the treatment of Duchenne muscular dysrophy is to increase expression of the dystrophin homolog utrophin. Here, the authors show that eEF1A2 regulates utrophin expression, and show that 2 FDA-approved drugs upregulate eEIF1A2 and utrophin level in mice, leading to improvement of the dystrophic phenotype.https://doi.org/10.1038/s41467-020-15971-w |
| spellingShingle | Christine Péladeau Nadine Adam Lucas M. Bronicki Adèle Coriati Mohamed Thabet Hasanen Al-Rewashdy Jason Vanstone Alan Mears Jean-Marc Renaud Martin Holcik Bernard J. Jasmin Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles Nature Communications |
| title | Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles |
| title_full | Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles |
| title_fullStr | Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles |
| title_full_unstemmed | Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles |
| title_short | Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles |
| title_sort | identification of therapeutics that target eef1a2 and upregulate utrophin a translation in dystrophic muscles |
| url | https://doi.org/10.1038/s41467-020-15971-w |
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