Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study
BackgroundInsufficient data exists regarding the relationship between body mass index (BMI) and the prognosis of chronic heart failure (CHF) specifically within low- and middle-income Asian countries. The objective of this study was to evaluate the impact of BMI on adverse outcomes of ambulatory pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1251601/full |
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| author | Hoai Thi Thu Nguyen Hoai Thi Thu Nguyen Thuong Thi Thu Ha Hieu Ba Tran Hieu Ba Tran Dung Viet Nguyen Dung Viet Nguyen Hung Manh Pham Hung Manh Pham Phuong Minh Tran Tuan Minh Pham Tuan Minh Pham Thomas G. Allison Christopher M. Reid Christopher M. Reid James N. Kirkpatrick James N. Kirkpatrick |
| author_facet | Hoai Thi Thu Nguyen Hoai Thi Thu Nguyen Thuong Thi Thu Ha Hieu Ba Tran Hieu Ba Tran Dung Viet Nguyen Dung Viet Nguyen Hung Manh Pham Hung Manh Pham Phuong Minh Tran Tuan Minh Pham Tuan Minh Pham Thomas G. Allison Christopher M. Reid Christopher M. Reid James N. Kirkpatrick James N. Kirkpatrick |
| author_sort | Hoai Thi Thu Nguyen |
| collection | DOAJ |
| description | BackgroundInsufficient data exists regarding the relationship between body mass index (BMI) and the prognosis of chronic heart failure (CHF) specifically within low- and middle-income Asian countries. The objective of this study was to evaluate the impact of BMI on adverse outcomes of ambulatory patients with CHF in Vietnam.MethodsBetween 2018 and 2020, we prospectively enrolled consecutive outpatients with clinically stable CHF in an observational cohort, single-center study. The participants were stratified according to Asian-specific BMI thresholds. The relationships between BMI and adverse outcomes (all-cause death and all-cause hospitalization) were analyzed by Kaplan–Meier survival curves and Cox proportional-hazards model.ResultsAmong 320 participants (age 63.5 ± 13.3 years, 57.9% male), the median BMI was 21.4 kg/m2 (IQR 19.5–23.6), and 10.9% were underweight (BMI <18.50 kg/m2). Over a median follow-up time of 32 months, the cumulative incidence of all-cause mortality and hospitalization were 5.6% and 19.1%, respectively. After multivariable adjustment, underweight patients had a significantly higher risk of all-cause mortality than patients with normal BMI (adjusted hazard ratios = 3.03 [95% CI: 1.07–8.55]). Lower BMI remained significantly associated with a worse prognosis when analyzed as a continuous variable (adjusted hazard ratios = 1.27 [95% CI: 1.03–1.55] per 1 kg/m2 decrease for all-cause mortality). However, BMI was not found to be significantly associated with the risk of all-cause hospitalization (p > 0.05).ConclusionIn ambulatory patients with CHF in Vietnam, lower BMI, especially underweight status (BMI < 18.5 kg/m2), was associated with a higher risk of all-cause mortality. These findings suggest that BMI should be considered for use in risk classification, and underweight patients should be managed by a team consisting of cardiologists, nutritionists, and geriatricians. |
| first_indexed | 2024-03-09T14:01:56Z |
| format | Article |
| id | doaj.art-6bc7fe2a64c74ba59763305e809348e4 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-09T14:01:56Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-6bc7fe2a64c74ba59763305e809348e42023-11-30T07:18:59ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12516011251601Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center studyHoai Thi Thu Nguyen0Hoai Thi Thu Nguyen1Thuong Thi Thu Ha2Hieu Ba Tran3Hieu Ba Tran4Dung Viet Nguyen5Dung Viet Nguyen6Hung Manh Pham7Hung Manh Pham8Phuong Minh Tran9Tuan Minh Pham10Tuan Minh Pham11Thomas G. Allison12Christopher M. Reid13Christopher M. Reid14James N. Kirkpatrick15James N. Kirkpatrick16Vietnam National Heart Institute, Bach Mai Hospital, Hanoi, VietnamDepartment of Internal Medicine, VNU-University of Medicine and Pharmacy, Hanoi, VietnamDepartment of Internal Medicine, VNU-University of Medicine and Pharmacy, Hanoi, VietnamVietnam National Heart Institute, Bach Mai Hospital, Hanoi, VietnamDepartment of Internal Medicine, VNU-University of Medicine and Pharmacy, Hanoi, VietnamVietnam National Heart Institute, Bach Mai Hospital, Hanoi, VietnamDepartment of Internal Medicine, VNU-University of Medicine and Pharmacy, Hanoi, VietnamVietnam National Heart Institute, Bach Mai Hospital, Hanoi, VietnamDepartment of Cardiology, Hanoi Medical University, Hanoi, VietnamVietnam National Heart Institute, Bach Mai Hospital, Hanoi, VietnamVietnam National Heart Institute, Bach Mai Hospital, Hanoi, VietnamDepartment of Cardiology, Hanoi Medical University, Hanoi, VietnamDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United StatesSchool of Population Health, Curtin University, Perth, WA, AustraliaSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, AustraliaCardiovascular Division, Department of Medicine, University of Washington Medical Center, Seattle, WA, United StatesDepartment of Bioethics and Humanities, University of Washington Medical Center, Seattle, WA, United StatesBackgroundInsufficient data exists regarding the relationship between body mass index (BMI) and the prognosis of chronic heart failure (CHF) specifically within low- and middle-income Asian countries. The objective of this study was to evaluate the impact of BMI on adverse outcomes of ambulatory patients with CHF in Vietnam.MethodsBetween 2018 and 2020, we prospectively enrolled consecutive outpatients with clinically stable CHF in an observational cohort, single-center study. The participants were stratified according to Asian-specific BMI thresholds. The relationships between BMI and adverse outcomes (all-cause death and all-cause hospitalization) were analyzed by Kaplan–Meier survival curves and Cox proportional-hazards model.ResultsAmong 320 participants (age 63.5 ± 13.3 years, 57.9% male), the median BMI was 21.4 kg/m2 (IQR 19.5–23.6), and 10.9% were underweight (BMI <18.50 kg/m2). Over a median follow-up time of 32 months, the cumulative incidence of all-cause mortality and hospitalization were 5.6% and 19.1%, respectively. After multivariable adjustment, underweight patients had a significantly higher risk of all-cause mortality than patients with normal BMI (adjusted hazard ratios = 3.03 [95% CI: 1.07–8.55]). Lower BMI remained significantly associated with a worse prognosis when analyzed as a continuous variable (adjusted hazard ratios = 1.27 [95% CI: 1.03–1.55] per 1 kg/m2 decrease for all-cause mortality). However, BMI was not found to be significantly associated with the risk of all-cause hospitalization (p > 0.05).ConclusionIn ambulatory patients with CHF in Vietnam, lower BMI, especially underweight status (BMI < 18.5 kg/m2), was associated with a higher risk of all-cause mortality. These findings suggest that BMI should be considered for use in risk classification, and underweight patients should be managed by a team consisting of cardiologists, nutritionists, and geriatricians.https://www.frontiersin.org/articles/10.3389/fnut.2023.1251601/fullchronic heart failurebody mass indexobesity paradoxunderweightmortalityhospitalization |
| spellingShingle | Hoai Thi Thu Nguyen Hoai Thi Thu Nguyen Thuong Thi Thu Ha Hieu Ba Tran Hieu Ba Tran Dung Viet Nguyen Dung Viet Nguyen Hung Manh Pham Hung Manh Pham Phuong Minh Tran Tuan Minh Pham Tuan Minh Pham Thomas G. Allison Christopher M. Reid Christopher M. Reid James N. Kirkpatrick James N. Kirkpatrick Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study Frontiers in Nutrition chronic heart failure body mass index obesity paradox underweight mortality hospitalization |
| title | Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study |
| title_full | Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study |
| title_fullStr | Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study |
| title_full_unstemmed | Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study |
| title_short | Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study |
| title_sort | relationship between bmi and prognosis of chronic heart failure outpatients in vietnam a single center study |
| topic | chronic heart failure body mass index obesity paradox underweight mortality hospitalization |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1251601/full |
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